{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T04:02:41Z","timestamp":1771905761664,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["279133"],"award-info":[{"award-number":["279133"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["279061"],"award-info":[{"award-number":["279061"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The cost\u2010effectiveness for screening for celiac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) in patients with irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>), specifically in the diarrhea (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010D) subtype, is beneficial if the prevalence is &gt;1%. However, recent studies have shown controversial results. In this large case\u2013control study, our aim was to determine the prevalence of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and a panel of related antibodies in patients diagnosed with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Four hundred <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients (Rome <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>) and 400 asymptomatic healthy controls were prospectively evaluated using antihuman tissue transglutaminase (h\u2010<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> IgA) and deamidated gliadin peptide antibodies (<jats:styled-content style=\"fixed-case\">DGP II<\/jats:styled-content> IgA and <jats:styled-content style=\"fixed-case\">DGP II<\/jats:styled-content> IgG). Duodenal biopsy was performed on the patients that were positive for the h\u2010<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> IgA and\/or <jats:styled-content style=\"fixed-case\">DGP II<\/jats:styled-content> IgG antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the population was 44.47\u00a0\u00b1\u00a018.01\u00a0years and 335 (82%) of the subjects were women. Twenty\u2010one patients and six controls had at least one positive test for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> (5.25% <jats:italic>VS<\/jats:italic> 1.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.63 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.4\u20139.11]). Eighteen patients were positive for h\u2010<jats:styled-content style=\"fixed-case\">tTG<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">DGP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> IgG. Histologic confirmation of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> was 2.5% in the <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients <jats:italic>vs<\/jats:italic> 0.5% in the controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.21). The <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010D subtype had the highest prevalence for serological positivity (12.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Up to 5.2% of the patients with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> according to the Rome <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> criteria were positive for at least one of the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\u2010related antibodies and 2.5% had biopsy\u2010confirmed <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. Therefore, in our population, screening for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> in subjects with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> appears to be a reasonable strategy, especially in the <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010D subgroup.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12799","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T03:17:52Z","timestamp":1456456672000},"page":"994-1000","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence of celiac disease and related antibodies in patients diagnosed with irritable bowel syndrome according to the Rome <scp>III<\/scp> criteria. A case\u2013control study"],"prefix":"10.1111","volume":"28","author":[{"given":"L. A.","family":"S\u00e1nchez\u2010Vargas","sequence":"first","affiliation":[{"name":"Gastrointestinal Motility and Digestive Physiology Laboratory Medical and Biological Research Institute of the Universidad Veracruzana Veracruz Veracruz Mexico"},{"name":"Doctorate in Biomedical Sciences Universidad Veracruzana Xalapa Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Thomas\u2010Dupont","sequence":"additional","affiliation":[{"name":"Gastrointestinal Motility and Digestive Physiology Laboratory Medical and Biological Research Institute of the Universidad Veracruzana Veracruz Veracruz Mexico"},{"name":"Doctorate in Biomedical Sciences Universidad Veracruzana Xalapa Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Torres\u2010Aguilera","sequence":"additional","affiliation":[{"name":"Gastrointestinal Motility and Digestive Physiology Laboratory Medical and Biological Research Institute of the Universidad Veracruzana Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Azamar\u2010Jacome","sequence":"additional","affiliation":[{"name":"Gastrointestinal Motility and Digestive Physiology Laboratory Medical and Biological Research Institute of the Universidad Veracruzana Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. L.","family":"Ram\u00edrez\u2010Ceervanes","sequence":"additional","affiliation":[{"name":"Gastrointestinal Motility and Digestive Physiology Laboratory Medical and Biological Research Institute of the Universidad Veracruzana Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Aedo\u2010Garc\u00e9s","sequence":"additional","affiliation":[{"name":"Gastrointestinal Motility and Digestive Physiology Laboratory Medical and Biological Research Institute of the Universidad Veracruzana Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Meixueiro\u2010Daza","sequence":"additional","affiliation":[{"name":"Gastrointestinal Motility and Digestive Physiology Laboratory Medical and Biological Research Institute of the Universidad Veracruzana Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Roesch\u2010Dietlen","sequence":"additional","affiliation":[{"name":"Gastrointestinal Motility and Digestive Physiology Laboratory Medical and Biological Research Institute of the Universidad Veracruzana Veracruz Veracruz Mexico"},{"name":"Faculty of Medicine Miguel Alem\u00e1n Vald\u00e9s Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Grube\u2010Pagola","sequence":"additional","affiliation":[{"name":"Gastrointestinal Motility and Digestive Physiology Laboratory Medical and Biological Research Institute of the Universidad Veracruzana Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Vivanco\u2010Cid","sequence":"additional","affiliation":[{"name":"Gastrointestinal Motility and Digestive Physiology Laboratory Medical and Biological Research Institute of the Universidad Veracruzana Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Remes\u2010Troche","sequence":"additional","affiliation":[{"name":"Gastrointestinal Motility and Digestive Physiology Laboratory Medical and Biological Research Institute of the Universidad Veracruzana Veracruz Veracruz Mexico"},{"name":"Faculty of Medicine Miguel Alem\u00e1n Vald\u00e9s Veracruz Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0210-5705(03)70470-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.07027.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010015\u20100229\u2010y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06581-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4065\/79.4.476"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01666.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/028134300750018990"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200304000-00012"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"A147","article-title":"Screening for celiac sprue in patients with suspected irritable bowel syndrome: results from a prospective US multi\u2010center trial","volume":"132","author":"Chey WD","year":"2007","journal-title":"Gastroenterology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0082-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"S 463","DOI":"10.14309\/00000434-200809001-01185","article-title":"Utility of diagnostic tests for celiac diseases in irritable bowel syndrome: systematic review and meta\u2010analysis","volume":"1","author":"Ford AC","year":"2008","journal-title":"Am J Gastro"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.22"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.03.012"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.79"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.084"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.05.014"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/45.12.2142"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02018.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i25.3144"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102011\u2010301346"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.408"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29572"},{"issue":"4","key":"e_1_2_10_25_1","first-page":"A193","article-title":"Prevalence of coeliac disease in IBS patients in Turin [abstract]","volume":"122","author":"DeMarchi B","year":"2002","journal-title":"Gastroenterology"},{"key":"e_1_2_10_26_1","first-page":"A198","article-title":"Low seroprevalence of celiac disease among patients with irritable bowel syndrome in Latvia [abstract]","volume":"53","author":"Funka K","year":"2004","journal-title":"Gut"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614561668"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.07023.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1007079"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajg.2012.03.003"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04110.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2007.03.028"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.007"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i27.8221"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7064966"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000435546.87251.f7"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.188"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12799","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T11:00:44Z","timestamp":1696503644000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,23]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/nmo.12799"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12799","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,23]]}}}