{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T07:14:50Z","timestamp":1769757290349,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T00:00:00Z","timestamp":1456531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005992","name":"Ministry of Education, Culture, and Science","doi-asserted-by":"crossref","award":["24590928"],"award-info":[{"award-number":["24590928"]}],"id":[{"id":"10.13039\/501100005992","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study is to clarify whether acotiamide and rabeprazole combination therapy can improve clinical symptoms, gastric emptying, and satisfaction with treatment in functional dyspepsia (FD) patients more effectively than acotiamide or rabeprazole monotherapy alone. We also aimed to determine whether acotiamide affects these changes via its effect on gastric emptying and appetite\u2010related hormones such as ghrelin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used Rome III criteria to evaluate upper abdominal symptoms and anxiety by the State\u2010Trait Anxiety Inventory (<jats:styled-content style=\"fixed-case\">STAI<\/jats:styled-content>). Gastric motility was evaluated by the<jats:sup>13<\/jats:sup>C\u2010acetate breath test. Eighty\u2010one<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>patients were treated with acotiamide (300 mg\/day) (<jats:italic>n<\/jats:italic>= 35), acotiamide (300 mg\/day) and rabeprazole (10 mg\/day) (<jats:italic>n<\/jats:italic>= 28), or rabeprazole (10 mg\/day) (<jats:italic>n<\/jats:italic>= 18) for a period of 4 weeks and followed after 4 weeks of no treatment. Adenocorticotropic hormone (ACTH), cortisol, leptin and ghrelin levels were measured in all<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Acotiamide and rabeprazole combination therapy significantly improved postprandial distress syndrome (PDS)\u2010like symptoms (<jats:italic>p<\/jats:italic>= 0.018,<jats:italic>p<\/jats:italic>= 0.04 and<jats:italic>p<\/jats:italic>= 0.041, respectively) and epigastric pain (<jats:italic>p<\/jats:italic>= 0.024) as wells as<jats:styled-content style=\"fixed-case\">STAI<\/jats:styled-content>\u2010state scores (<jats:italic>p<\/jats:italic>= 0.04) compared to rabeprazole monotherapy. Both acotiamide monotherapy, and acotiamide taken in combination with rabeprazole, significantly (<jats:italic>p<\/jats:italic>= 0.001 and<jats:italic>p<\/jats:italic>= 0.02, respectively) improved satisfaction with treatment, compared to rabeprazole monotherapy. Acotiamide and rabeprazole combination therapy had no significant effect on<jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>and cortisol levels in<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>patients. Of interest, acotiamide monotherapy, and acotiamide and rabeprazole combination therapy, significantly (<jats:italic>p<\/jats:italic>&lt; 0.0001 and<jats:italic>p<\/jats:italic>= 0.018, respectively) increased acylated ghrelin\/total ghrelin ratios and significantly (<jats:italic>p<\/jats:italic>= 0.04) improved impaired gastric emptying compared to rabeprazole monotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Further studies are warranted to clarify how acotiamide treatment improves clinical symptoms in<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12805","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T14:43:47Z","timestamp":1456584227000},"page":"1037-1047","source":"Crossref","is-referenced-by-count":21,"title":["Improvement of meal\u2010related symptoms and epigastric pain in patients with functional dyspepsia 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