{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:19:23Z","timestamp":1787761163849,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Internal Medicine at Texas Tech University Health Sciences Center\/Paul L. Foster School of Medicine Seed"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Depletion and ultrastructural changes of interstitial cells of Cajal (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>) in the gastric body and antrum have been observed in gastroparesis. This research was performed to investigate the <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> population in the muscularis propria and fibrosis of the muscular layer of the pylorus in gastroparesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Full thickness pyloric and antral biopsies were obtained from 17 gastroparetic and 6 non\u2010gastroparetic controls. Biopsies were stained with C\u2010Kit for <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> and Trichrome for collagen fibrosis. Interstitial cells of Cajal depletion in the antrum was defined as mean <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> count &lt;10 per 20 high power fields (<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>) based on established data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The average pyloric <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> count was \u226510\/<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content> in the control patients. Twelve (70.5%) gastroparetic patients had pyloric <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> loss. Only five patients (29.4%) had <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> loss in the antrum. Gastric emptying (<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>) was not significantly different in patients with depleted <jats:italic>vs<\/jats:italic> normal pyloric <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>. However, <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content> at 2 h was slower in patients with antral <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> &lt;10\/<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content> compared to those with normal antral <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> populations. Collagen fibrosis was observed in the pylorus of 14 (82.3%) patients. Inclusion bodies in the muscularis propria of the pylorus were identified in four patients, all with diabetic gastroparesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In gastroparetic patients, <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> loss in the pylorus is twice as common as in the antrum and fibrosis in the pyloric smooth muscle is nearly three times more common than the antrum. These findings can provide one explanation for pyloric dysfunction which is a contributing factor to the pathophysiology of gastroparesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12806","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T16:58:06Z","timestamp":1457197086000},"page":"1048-1054","source":"Crossref","is-referenced-by-count":72,"title":["Depleted interstitial cells of Cajal and fibrosis in the pylorus: Novel features of gastroparesis"],"prefix":"10.1111","volume":"28","author":[{"given":"S.","family":"Moraveji","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Sciences Center\/Paul L. Foster School of Medicine El Paso TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bashashati","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Texas Tech University Health Sciences Center\/Paul L. 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