{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:01:02Z","timestamp":1792735262049,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T00:00:00Z","timestamp":1456531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001845","name":"Scleroderma Research Foundation","doi-asserted-by":"publisher","award":["P60AR064464"],"award-info":[{"award-number":["P60AR064464"]}],"id":[{"id":"10.13039\/100001845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["UL1TR000159"],"award-info":[{"award-number":["UL1TR000159"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n We aimed to evaluate the associations between systemic sclerosis (\n SS<\/jats:styled-content>\n c)\u2010related systemic manifestations and esophageal function using high\u2010resolution manometry (\n HRM<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with\n SS<\/jats:styled-content>\n c that had undergone\n HRM<\/jats:styled-content>\n between 1\/2004 and 9\/2014 were identified and\n HRM<\/jats:styled-content>\n s were analyzed according to the Chicago Classification. Clinical characteristics were identified via retrospective chart review and compared among motility diagnoses while adjusting for age, gender, race, and\n SS<\/jats:styled-content>\n c\u2010disease duration.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n Seventy\u2010nine patients (85% female, ages 25\u201377) were included. Clinical characteristics were compared between patients with absent contractility (\n AC<\/jats:styled-content>\n ,\n n<\/jats:italic>\n = 40), ineffective esophageal motility (\n IEM<\/jats:styled-content>\n ;\n n<\/jats:italic>\n = 15), and normal motility (\n n<\/jats:italic>\n = 19); the five remaining patients met criteria for other motility diagnoses. Groups differed in severity of skin involvement measured by the modified Rodnan skin score (0\u201351):\n AC<\/jats:styled-content>\n (adjusted mean 12.6),\n IEM<\/jats:styled-content>\n (4.4), normal (4.3),\n p<\/jats:italic>\n = 0.043. Pulmonary function tests [percent predicted\n FVC<\/jats:styled-content>\n and\n DLCO<\/jats:styled-content>\n ) were lower in\n AC<\/jats:styled-content>\n (adjusted mean,\n FVC<\/jats:styled-content>\n : 70.3,\n DLCO<\/jats:styled-content>\n 51.1), than\n IEM<\/jats:styled-content>\n (\n FVC<\/jats:styled-content>\n : 92.0;\n DLCO<\/jats:styled-content>\n : 76.9) and normal motility (\n FVC<\/jats:styled-content>\n : 80.0;\n DLCO<\/jats:styled-content>\n : 67.2),\n p<\/jats:italic>\n values 0.057 (\n FVC<\/jats:styled-content>\n ) and 0.007 (\n DLCO<\/jats:styled-content>\n ). Groups did not differ by\n SS<\/jats:styled-content>\n c\u2010disease duration, autoantibodies, or reported symptoms of dysphagia or reflux.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n In patients with\n SS<\/jats:styled-content>\n c, absent esophageal contractility on\n HRM<\/jats:styled-content>\n was associated with increased skin disease severity and worse lung function. Obtaining\n HRM<\/jats:styled-content>\n to identify\n SS<\/jats:styled-content>\n c patients with more severe esophageal dysfunction could be considered to enable implementation of management strategies in patients potentially at risk for increased morbidity and mortality.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.12813","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T09:43:54Z","timestamp":1456566234000},"page":"1157-1165","source":"Crossref","is-referenced-by-count":79,"title":["The association between systemic sclerosis disease manifestations and esophageal high\u2010resolution manometry parameters"],"prefix":"10.1111","volume":"28","author":[{"given":"J. N.","family":"Kimmel","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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