{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:59:03Z","timestamp":1790855943299,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:00:00Z","timestamp":1461628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) is the commonest disabling neurological disease in young adults. A majority of patients experience bowel dysfunction, reporting a wide spectrum of bowel symptoms that significantly negatively impact social activities and emotional state. Transanal irrigation (<jats:styled-content style=\"fixed-case\">TAI<\/jats:styled-content>) is a method of managing such bowel symptoms. We aimed to investigate long\u2010term efficacy of <jats:styled-content style=\"fixed-case\">TAI<\/jats:styled-content>, to measure health status\u2010related quality of life and identify factors predictive of <jats:styled-content style=\"fixed-case\">TAI<\/jats:styled-content> outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010nine consecutive <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients (37 female; mean age 51, range 26\u201080) were studied. We investigated predominant symptoms, reason for beginning <jats:styled-content style=\"fixed-case\">TAI<\/jats:styled-content> and medical comorbidity. All patients underwent anorectal physiology testing. They completed Neurogenic Bowel Dysfunction and <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D questionnaires at baseline and annual follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Mean follow\u2010up was 40 months, at which there was 55% rate of continuation of <jats:styled-content style=\"fixed-case\">TAI<\/jats:styled-content>. Severe bowel dysfunction was present in 47% at baseline, falling to 18%. The <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D scores at latest follow\u2010up were not statistically significant, but 42% had improved visual analog scores. The only predictive factor for successful therapy was impaired anal electrosensitivity (<jats:italic>p<\/jats:italic> = 0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Long\u2010term continuation of <jats:styled-content style=\"fixed-case\">TAI,<\/jats:styled-content> with improved bowel symptomatology, is seen in the majority of patients. The <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D is insufficiently sensitive to show change in <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients that using <jats:styled-content style=\"fixed-case\">TAI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12833","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T14:24:27Z","timestamp":1461767067000},"page":"1349-1355","source":"Crossref","is-referenced-by-count":37,"title":["Long\u2010term efficacy and safety of transanal irrigation in multiple sclerosis"],"prefix":"10.1111","volume":"28","author":[{"given":"V.","family":"Passananti","sequence":"first","affiliation":[{"name":"GI Physiology Unit University College London Hospital and National Hospital for Neurology &amp; Neurosurgery London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wilton","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Preziosi","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College London Hospital and National Hospital for Neurology &amp; Neurosurgery London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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