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As there is no unifying mechanism with a direct link to chronic nausea or vomiting, it is most likely that several mechanisms interact, e.g., pylorus function and its relation to gastric emptying, or gastric sensory and motor function. In this mini\u2010review, we highlight the roles and evidence for brain\u2013gut interactions as well as gastrointestinal neurophysiologic, motor, sensory, and hormonal factors involved in the pathophysiology of chronic nausea and vomiting. There are factors not mentioned in the text, mostly as they are not well characterized in the setting of chronic symptoms or only in animal models.<\/jats:p>","DOI":"10.1111\/nmo.12837","type":"journal-article","created":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T11:37:36Z","timestamp":1461411456000},"page":"613-619","source":"Crossref","is-referenced-by-count":10,"title":["Chronic nausea and vomiting: insights into underlying mechanisms"],"prefix":"10.1111","volume":"28","author":[{"given":"H.","family":"T\u00f6rnblom","sequence":"first","affiliation":[{"name":"Department of Internal Medicine &amp; Clinical Nutrition Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Abrahamsson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine &amp; Clinical Nutrition Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg 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