{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:45:48Z","timestamp":1790034348156,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:00:00Z","timestamp":1461024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2012K2A2A4010622"],"award-info":[{"award-number":["2012K2A2A4010622"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["12032211\u2010000109"],"award-info":[{"award-number":["12032211\u2010000109"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Capsaicin is an ingredient of red peppers that binds to transient receptor potential vanilloid subtype 1 (\n                      <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>\n                      1), and Koreans eat more capsaicin\u2010rich food than do Japanese. This study aimed to compare symptom generation according to\n                      <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>\n                      1 genotypes and the intake of spicy foods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Consecutive functional dyspepsia (\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      ) patients who were evaluated at Konkuk University Medical Centre (Korea) and Keio University Hospital (Japan) were included. Questionnaires on spicy food intake, patient assessment of gastrointestinal symptoms (\n                      <jats:styled-content style=\"fixed-case\">PAGI<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">SYM<\/jats:styled-content>\n                      ), patient assessment of quality of life, and hospital anxiety and depression scale were provided. Blood was sampled for the detection of\n                      <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>\n                      1 polymorphisms, and upper gastrointestinal endoscopy was performed with biopsies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Of 121 included subjects, 35 and 28 carried the\n                      <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>\n                      1\n                      <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content>\n                      genotypes, respectively, with the prevalence rates not differing between Japan and Korea. The prevalence of\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      subtypes did not differ with the spicy food intake,\n                      <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>\n                      1 genotypes, or\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection. Neither\n                      <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>\n                      1 polymorphisms nor\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infections were related to scores on the\n                      <jats:styled-content style=\"fixed-case\">PAGI<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">SYM<\/jats:styled-content>\n                      questionnaires, but spicy food intake was positively correlated with the scores for stomach fullness (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001) and retching (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001). Using the linear regression analysis, stomach fullness was associated with spicy food intake (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007), whereas retching was related to younger age (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and female gender (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      Upper gastrointestinal symptoms are more common in subjects with a higher consumption of spicy foods, younger age and female gender, regardless of\n                      <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>\n                      1 genotypes and the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection status. Capsaicin\u2010rich foods may induce stomach fullness.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12841","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T22:44:17Z","timestamp":1461105857000},"page":"1401-1408","source":"Crossref","is-referenced-by-count":30,"title":["A prospective study on symptom generation according to spicy food intake and\n                    <scp>TRPV<\/scp>\n                    1 genotypes in functional dyspepsia patients"],"prefix":"10.1111","volume":"28","author":[{"given":"S.\u2010Y.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Konkuk University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Masaoka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology Konkuk University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Konkuk University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Konkuk University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"},{"name":"Medical Education Center Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01280.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01766.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2002.00353.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1740-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.138982"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01167.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12596"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181b5745e"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12044"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01734.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00682.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01227.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03022.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00997.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04564.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9180-7"},{"key":"e_1_2_10_18_1","first-page":"396","article-title":"Capsaicin induction of esophageal symptoms in different phenotypes of gastroesophageal reflux disease","volume":"75","author":"Herrera\u2010L\u00f3pez JA","year":"2010","journal-title":"Rev Gastroenterol Mex"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.1.54"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13146"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14165"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14045"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15016"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12841","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T10:05:01Z","timestamp":1696154701000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,19]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/nmo.12841"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12841","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726298822.793517397","asserted-by":"object"}]},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,19]]}}}