{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T22:43:01Z","timestamp":1775601781911,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T00:00:00Z","timestamp":1462406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 DK84113"],"award-info":[{"award-number":["K23 DK84113"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>) is a common abdominal pain disorder without an organic explanation. Abuse histories (physical, sexual, emotional) are prevalent in <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>. While abuse relates to mood disorders (depression and anxiety) also common in <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>, the influence of abuse on gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) symptoms and health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content>) and its independence from psychological symptom comorbidity has not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> outpatients completed the <jats:styled-content style=\"fixed-case\">ROME III<\/jats:styled-content> Research Diagnostic Questionnaire and questionnaires on trauma (Life\u2010Stress Questionnaire), mood (Beck Depression\/Anxiety Inventories), somatic symptoms (<jats:styled-content style=\"fixed-case\">PHQ<\/jats:styled-content>\u201012), and <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036). Current <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> symptom severity and bother were assessed using 10\u2010cm Visual Analog Scales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>272 <jats:styled-content style=\"fixed-case\">ROME<\/jats:styled-content>\u2010defined <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> (47.6 \u00b1 0.9 years, 81% female) and 246 non\u2010<jats:styled-content style=\"fixed-case\">FGID<\/jats:styled-content> (51.6 \u00b1 1.0 years, 65% female) subjects participated. <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients reported greater rates of physical, sexual, and emotional abuse (<jats:italic>p<\/jats:italic> &lt; 0.006 each), and higher depression, anxiety, and somatic symptoms (<jats:italic>p<\/jats:italic> &lt; 0.001). Greater bowel symptom bother (7.4 \u00b1 0.2 <jats:italic>vs<\/jats:italic> 6.7 \u00b1 0.2, <jats:italic>p<\/jats:italic> = 0.040), severity (7.7 \u00b1 0.2 <jats:italic>vs<\/jats:italic> 6.5 \u00b1 0.2, <jats:italic>p<\/jats:italic> &lt; 0.001), recent symptomatic days (9.8 \u00b1 0.4 <jats:italic>vs<\/jats:italic> 8.5 \u00b1 0.3, <jats:italic>p<\/jats:italic> = 0.02), and poorer <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> (40.9 \u00b1 2.3 <jats:italic>vs<\/jats:italic> 55.5 \u00b1 1.7, <jats:italic>p<\/jats:italic> &lt; 0.001) were noted in <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> with abuse. Abuse effects were additive, with greater <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> symptom severity and poorer <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> noted in cases with multiple forms of abuse. Mediation analyses suggested that abuse effects on <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> symptoms and <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> were partially mediated by mood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Abuse experiences common among <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> sufferers are associated with reports of greater <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> symptoms and poorer <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content>, particularly in those with multiple forms of abuse; this relationship may be partially mediated by concomitant mood disturbances.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12848","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T04:46:47Z","timestamp":1462510007000},"page":"1508-1517","source":"Crossref","is-referenced-by-count":55,"title":["The impact of abuse and mood on bowel symptoms and health\u2010related quality of life in irritable bowel syndrome (<scp>IBS<\/scp>)"],"prefix":"10.1111","volume":"28","author":[{"given":"N.","family":"Kanuri","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Cassell","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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