{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:38:07Z","timestamp":1780673887958,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early life events have been found to be associated with irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>) suggesting a role in development of functional disorders. The study aim was to identify potential perinatal risk factors for adult <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Utilizing a population\u2010based nested case\u2013control design, cases who met modified Rome <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> criteria for <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> and age\u2010 and\u2010gender matched controls were identified using responses from prior mailed surveys to a random sample of Olmsted County residents. Medical records of eligible respondents were reviewed for perinatal events of interest. The association of early life events with subsequent case status was assessed using conditional logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Of 3 417 respondents, 513 were born in Olmsted County and 108 met criteria for <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>. Due to missing records, 89 pairs were included in the final analyses. Logistic regression revealed only birth weight as a predictor of <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>. Lower birth weight increased the odds for <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.54 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = (1.12, 2.08), <jats:italic>p<\/jats:italic> = 0.008]). Median birth weight was 3.35 kg (range: 1.96\u20135.24) and 3.57 kg (range: 2.18\u20134.59) for cases and controls, respectively. Maternal age, delivery method, and antibiotic exposure were not associated with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> status but this study was only powered to detect large odds ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Lower birth weight was observed as a risk factor for <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>. It is not clear if <jats:italic>in utero<\/jats:italic> developmental delays directly lead to <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> or if low birth weight is a prospective marker for subsequent early life problems leading to <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12849","type":"journal-article","created":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T01:17:24Z","timestamp":1463620644000},"page":"1518-1524","source":"Crossref","is-referenced-by-count":15,"title":["Irritable bowel syndrome and the perinatal period: lower birth weight increases the risk"],"prefix":"10.1111","volume":"28","author":[{"given":"D.","family":"Raslau","sequence":"first","affiliation":[{"name":"Department of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. M.","family":"Herrick","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"},{"name":"College of Nursing South Dakota State University Brookings SD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. R.","family":"Locke","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. D.","family":"Schleck","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Zinsmeister","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Almazar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Talley","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"},{"name":"University of Newcastle Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. 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