{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:45:05Z","timestamp":1782827105912,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T00:00:00Z","timestamp":1463961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatments for functional constipation (<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>) and irritable bowel syndrome with constipation (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C) differ, but symptom criteria do not reliably distinguish between them; some regard <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C as parts of a single constipation spectrum. Our goal was to review studies comparing <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C to identify possible biomarkers that separate them. A systematic review identified 15 studies that compared physiologic tests in <jats:styled-content style=\"fixed-case\">FC <\/jats:styled-content><jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C. Pain thresholds were lower in <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C than <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> for 3\/5 studies and not different in 2\/5. Colonic motility was decreased more in <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C for 3\/3 studies, and whole gut transit was delayed more in <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C in 3\/8 studies and not different in 5\/8. Pelvic floor dyssynergia was unrelated to diagnosis. Sympathetic arousal, measured in only one study, was greater in <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C than <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>. The most reliable separation of <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C was shown by a novel new magnetic resonance imaging technique described in this issue of the journal. These authors showed that drinking one liter of polyethylene glycol laxative significantly increased water content in the small intestine, volume of contents in the ascending colon, and time to first evacuation in <jats:styled-content style=\"fixed-case\">FC <\/jats:styled-content><jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C; and resulted in less colon motility and delayed whole gut transit in <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> compared to IBS\u2010C. Although replication is needed, this well\u2010tolerated, non\u2010invasive test promises to become a new standard for differential diagnosis of <jats:styled-content style=\"fixed-case\">FC <\/jats:styled-content><jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C. These data suggest that <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C are different disorders rather than points on a constipation spectrum.<\/jats:p>","DOI":"10.1111\/nmo.12852","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T15:17:01Z","timestamp":1464103021000},"page":"783-792","source":"Crossref","is-referenced-by-count":19,"title":["Biomarkers to distinguish functional constipation from irritable bowel syndrome with constipation"],"prefix":"10.1111","volume":"28","author":[{"given":"W. E.","family":"Whitehead","sequence":"first","affiliation":[{"name":"Center for Functional Gastrointestinal and Motility Disorders University of North Carolina at Chapel Hill Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. 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