{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:15:23Z","timestamp":1791591323510,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007343","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007343","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with functional heartburn (<jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>) experience troublesome heartburn that is not related to gastroesophageal reflux. The etiology of the heartburn sensation in <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> patients is unknown. In patients with reflux disease, esophageal hypersensitivity seems associated with impaired mucosal integrity. We aimed to determine esophageal sensitivity and mucosal integrity in <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> and non\u2010erosive reflux disease (<jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective experimental study, we performed an acid perfusion test and upper endoscopy with biopsies in 12 patients with <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> and nine patients with <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>. Mucosal integrity was measured during endoscopy using electrical tissue impedance spectroscopy and biopsy specimens were analyzed in Ussing chambers for transepithelial electrical resistance and transepithelial permeability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Lag time to heartburn perception was significantly longer in <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> patients (median 12 min) than in <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> patients (median 3 min). Once perceived, intensity of heartburn was scored equal with median visual analog scale 6.5 and 7.1 respectively. Esophageal mucosal integrity was also comparable between <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> patients, both <jats:italic>in vivo<\/jats:italic> extracellular impedance and <jats:italic>ex vivo<\/jats:italic> transepithelial resistance and permeability were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> did not show acid hypersensitivity as seen in patients with <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content>. However, once perceived, intensity of heartburn is similar. Esophageal mucosal integrity is similar between <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> patients, and is therefore unlikely to be the underlying cause of the observed difference in esophageal acid perception.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12864","type":"journal-article","created":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T12:13:52Z","timestamp":1463660032000},"page":"1649-1654","source":"Crossref","is-referenced-by-count":34,"title":["Esophageal acid sensitivity and mucosal integrity in patients with functional heartburn"],"prefix":"10.1111","volume":"28","author":[{"given":"P. W.","family":"Weijenborg","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J. P. M.","family":"Smout","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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