{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T05:42:37Z","timestamp":1769751757804,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["APRC\u201093\u201011"],"award-info":[{"award-number":["APRC\u201093\u201011"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to evaluate the role of H<jats:sub>2<\/jats:sub>S on gastric emptying rate (<jats:styled-content style=\"fixed-case\">GER<\/jats:styled-content>) and also to determine the effect of gastric distention on <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and protein expression of cystathionine \u03b2\u2010lyase (<jats:styled-content style=\"fixed-case\">CBS<\/jats:styled-content>) and cystathionine \u03b3\u2010synthase (<jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>) in diabetic\u2010gastroparetic and normal rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult normal rats intraperitoneally received either propargylglycine (<jats:styled-content style=\"fixed-case\">PAG<\/jats:styled-content>), L\u2010cysteine or Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> 30 min prior to <jats:styled-content style=\"fixed-case\">GER<\/jats:styled-content> marker (acetaminophen) to investigate H<jats:sub>2<\/jats:sub>S involvement in <jats:styled-content style=\"fixed-case\">GER<\/jats:styled-content> and the same protocols were performed in diabetes\u2010induced gastroparesis rats. The role of calcitonin gene related peptide (<jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>) neurons in the prokinetic effect of endogenous H<jats:sub>2<\/jats:sub>S on <jats:styled-content style=\"fixed-case\">GER<\/jats:styled-content> was determined. The level of <jats:styled-content style=\"fixed-case\">CBS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content> expressions in response to gastric distention were also determined. The effect of H<jats:sub>2<\/jats:sub>S on frequency and tension of spontaneous contractions of gastric smooth muscle strips was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Our results showed that: (i) H<jats:sub>2<\/jats:sub>S and L\u2010cysteine increased <jats:styled-content style=\"fixed-case\">GER<\/jats:styled-content> in gastroparetic and normal rats. (ii) The increased levels of <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content> expression in response to gastric distention in diabetic rats were lower than in normal rats. (iii) <jats:styled-content style=\"fixed-case\">PAG<\/jats:styled-content> inhibited the excitatory effect of capsaicin on <jats:styled-content style=\"fixed-case\">GER<\/jats:styled-content> and on tension of spontaneous contractions of strips. (iv) Hydrogen sulphide increased the frequency and tension of spontaneous contractions of gastric strip muscles in normal and diabetic rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>The results showed that delayed <jats:styled-content style=\"fixed-case\">GER<\/jats:styled-content> in diabetic rats can be due to down\u2010regulation of H<jats:sub>2<\/jats:sub>S biosynthesis enzyme, <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content> and suggested that a potential prokinetic role for H<jats:sub>2<\/jats:sub>S to treat the delayed gastric emptying in diabetic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12867","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T03:50:16Z","timestamp":1466567416000},"page":"1677-1689","source":"Crossref","is-referenced-by-count":13,"title":["Delayed gastric emptying in diabetic rats caused by decreased expression of cystathionine gamma lyase and H<sub>2<\/sub>S synthesis: <i>in vitro<\/i> and <i>in vivo<\/i> studies"],"prefix":"10.1111","volume":"28","author":[{"given":"S. A.","family":"Mard","sequence":"first","affiliation":[{"name":"Physiology Research Center (PRC) Research Center for Infectious Diseases of Digestive System Dept. of Physiology School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Physiology Research Center (PRC) Research Center for Infectious Diseases of Digestive System Dept. of Physiology School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ahangarpour","sequence":"additional","affiliation":[{"name":"Physiology Research Center (PRC) Dept. of Physiology School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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