{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:00:43Z","timestamp":1791475243389,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000135"],"award-info":[{"award-number":["UL1 TR000135"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1\u2010DK67071"],"award-info":[{"award-number":["RO1\u2010DK67071"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PO1\u2010DK68055"],"award-info":[{"award-number":["PO1\u2010DK68055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Synthetic human ghrelin accelerates gastric emptying, reduces gastric accommodation, and results in numerical increases in postprandial symptom scores. The ghrelin receptor agonist, relamorelin, accelerates gastric emptying in patients with diabetic gastroparesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To measure pharmacological effects of relamorelin on gastric accommodation, distal antral motility, and satiation in healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a placebo\u2010controlled, double\u2010blind, randomized study of 16 healthy volunteers, we compared effects of 30 <jats:italic>\u03bc<\/jats:italic>g subcutaneous (s.c.) relamorelin to placebo on: (i) gastric volumes measured by single photon emission computed tomography, (ii) 1\u2010h postprandial distal antral motility index (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>) by 15\u2010lumen perfusion gastroduodenal manometry, and (iii) satiation tested by Ensure nutrient drink test. Primary endpoints were: fasting and postprandial gastric volumes, distal antral phasic pressure activity (number of contractions, mean amplitude, and <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>), and maximum tolerated volume. Results were normally distributed and the two treatment groups were compared using <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Relamorelin, 30 <jats:italic>\u03bc<\/jats:italic>g s.c., significantly increased the number of contractions in the distal antrum during 0\u201360 min postmeal when compared to placebo (<jats:italic>p<\/jats:italic> = 0.022); this was also observed in the first two 15\u2010min periods (<jats:italic>p<\/jats:italic> = 0.005 and 0.015 for number of contractions 0\u201315 and 16\u201330). There was borderline increase in <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content><jats:sub>0\u201015<\/jats:sub> (<jats:italic>p<\/jats:italic> = 0.055) and numerically increased <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content><jats:sub>0\u201060<\/jats:sub> (<jats:italic>p<\/jats:italic> = 0.139) and <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content><jats:sub>16\u201030<\/jats:sub> (<jats:italic>p<\/jats:italic> = 0.116). The amplitude of contractions was not significantly increased. Relamorelin did not significantly alter fasting or postprandial gastric volumes, gastric accommodation, or satiation volumes and symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Relamorelin increases frequency of distal antral motility contractions without significant effects on amplitude of contractions. The lack of inhibition of accommodation and absence of increase in satiation symptoms support relamorelin for the treatment of symptomatic gastroparesis (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>02466711).<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12870","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T03:22:50Z","timestamp":1465528970000},"page":"1705-1713","source":"Crossref","is-referenced-by-count":52,"title":["Effects of ghrelin receptor agonist, relamorelin, on gastric motor functions and satiation in healthy volunteers"],"prefix":"10.1111","volume":"28","author":[{"given":"A. 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