{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:24:59Z","timestamp":1784366699085,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1064835"],"award-info":[{"award-number":["1064835"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The pathogenesis of slow transit constipation (<jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content>) remains poorly understood, with intrinsic and extrinsic abnormalities implicated. Here, we present high\u2010resolution colonic manometry recordings from four <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content> patients recorded before total colectomy, and subsequently, <jats:italic>ex vivo<\/jats:italic>, after excision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In four female, treatment\u2010resistant <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content> patients (median age 35.5 years), a fiber\u2010optic manometry catheter (72 sensors spaced at 1 cm intervals) was placed with the aid of a colonoscope, to the mid\u2010transverse colon. Colonic manometry was recorded 2 h before and after a meal. After the colectomy, <jats:italic>ex vivo<\/jats:italic> colonic manometry was recorded in an organ bath. <jats:italic>Ex vivo<\/jats:italic> recordings were also made from colons from 4 patients (2 male; median age 67.5 years) undergoing anterior resection for nonobstructive carcinoma (\u2018control\u2019 tissue).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>A large increase in \u2018short single propagating contractions\u2019 was recorded in <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content> colon <jats:italic>ex vivo<\/jats:italic> compared to <jats:italic>in vivo<\/jats:italic> (<jats:italic>ex vivo<\/jats:italic> 61.3 \u00b1 32.7 <jats:italic>vs in vivo<\/jats:italic> 2.5 \u00b1 5\/h). In <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content> patients, <jats:italic>in vivo<\/jats:italic>, the dominant frequency of contractile activity was 2\u20133 cycle per minute (cpm), whereas 1\u2010cpm short\u2010single propagating contractions dominated <jats:italic>ex vivo<\/jats:italic>. This same 1\u2010cpm frequency was also dominant in control colons <jats:italic>ex vivo<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In comparison to control adults, the colon of <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content> patients demonstrates significantly less propagating motor activity. However, once the <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content> colon is excised from the body it demonstrates a regular and similar frequency of propagating activity to control tissue. This paper provides interesting insights into the control of colonic motor patterns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12884","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T03:43:08Z","timestamp":1465530188000},"page":"1824-1835","source":"Crossref","is-referenced-by-count":34,"title":["High\u2010resolution colonic motility recordings <i>in vivo<\/i> compared with <i>ex vivo<\/i> recordings after colectomy, in patients with slow transit constipation"],"prefix":"10.1111","volume":"28","author":[{"given":"P. G.","family":"Dinning","sequence":"first","affiliation":[{"name":"Disciplines of Human Physiology Flinders University Bedford Park SA Australia"},{"name":"Departments of Gastroenterology and Surgery Flinders Medical Centre Bedford Park SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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