{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:30:17Z","timestamp":1792467017264,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T00:00:00Z","timestamp":1469923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Short\u2010chain fructooligosaccharides (sc<jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content>) have beneficial effects in subjects with minor digestive complaints, but the potential mechanisms involved have not been elucidated. The aim of the study was to evaluate changes in rectal sensitivity related to the clinical effects of sc<jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content> in a selected group of patients with irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>) and rectal hypersensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 79 <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients (defined by Rome <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> criteria) with rectal hypersensitivity (defined as discomfort threshold \u226444\u00a0g) a parallel, placebo\u2010controlled, randomized, and double\u2010blind study was performed to assess the effects of dietary supplementation (5\u00a0g\u00a0d<jats:sup>\u22121<\/jats:sup>) with sc<jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content> vs placebo for 4\u00a0weeks on rectal sensitivity (primary outcome: tolerance to increasing wall tension applied by a tensostat), clinical outcomes (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>, anxiety\/depression and quality of life scores) and composition of fecal microbiota.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Rectal discomfort threshold, and <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> and quality of life scores, significantly improved during treatment, but in a similar manner in both sc<jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content> and placebo groups; a post\u2010hoc analysis showed that the effect of sc<jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content> on rectal sensitivity was more pronounced in constipation\u2010predominant\u2010<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic>=.051 vs placebo). Contrary with placebo, sc<jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content> significantly reduced anxiety scores and increased fecal Bifidobacteria (<jats:italic>P<\/jats:italic>&lt;.05 for both) without modifying other bacterial groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Interfences<\/jats:title><jats:p>The effect of sc<jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content> on anxiety may be related to modulation of the gut microbiota; demonstration of effects of sc<jats:styled-content style=\"fixed-case\">FOS<\/jats:styled-content> on rectal sensitivity may require higher doses and may depend on the <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> subgroup.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12911","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:57:06Z","timestamp":1485737826000},"source":"Crossref","is-referenced-by-count":133,"title":["Effects of sc<scp>FOS<\/scp> on the composition of fecal microbiota and anxiety in patients with irritable bowel syndrome: a randomized, double blind, placebo controlled study"],"prefix":"10.1111","volume":"29","author":[{"given":"F.","family":"Azpiroz","sequence":"first","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd)  Barcelona Spain"},{"name":"Departament de Medicina Universitat Aut\u00f2noma de Barcelona  Bellaterra (Cerdanyola del Vall\u00e8s) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dubray","sequence":"additional","affiliation":[{"name":"Inserm CIC\u2010501 Clinical Pharmacology Centre Clermont\u2010Ferrand Hospital  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bernalier\u2010Donadille","sequence":"additional","affiliation":[{"name":"UR454 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