{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:56:19Z","timestamp":1767974179120,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AstraZeneca SA"},{"name":"Nycomed Hellas SA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Functional dyspepsia (FD<\/jats:styled-content>) susceptibility might be influenced by polymorphisms of genes related to inflammation (CD<\/jats:styled-content>14<\/jats:italic>, macrophage migration inhibitory factor<\/jats:italic> [MIF<\/jats:styled-content><\/jats:italic>]), motor (GNB<\/jats:styled-content>3<\/jats:italic>), and sensory dysfunction (GNB<\/jats:styled-content>3, TRPV<\/jats:styled-content>1<\/jats:italic>). We examined the association between CD<\/jats:styled-content>14<\/jats:italic> rs2569190, GNB<\/jats:styled-content>3<\/jats:italic> rs5443, MIF<\/jats:styled-content><\/jats:italic> rs222747, and TRPV<\/jats:styled-content>1<\/jats:italic> rs755622 gene polymorphisms with FD<\/jats:styled-content> (Rome III criteria) in the Greek population.<\/jats:p><\/jats:sec>Methods<\/jats:title>We genotyped 174 dyspeptics (115 with epigastric pain syndrome; 41% Helicobacter pylori<\/jats:italic> positive) and 181 controls using polymerase chain reaction\u2010based methods and we measured disease symptoms\u2019 burden with a modified Gastrointestinal Symptoms Related Scale.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Homozygous for the TT<\/jats:styled-content> genotype and the T allele of the CD<\/jats:styled-content>14<\/jats:italic> gene were significantly associated (OR<\/jats:styled-content> [95% CI<\/jats:styled-content>]) with FD<\/jats:styled-content> (2.65 [1.42\u20134.94] and 1.67 [1.23\u20132.26], respectively). The CT<\/jats:styled-content>, TT<\/jats:styled-content> genotypes, and T allele frequencies of GNB<\/jats:styled-content>3<\/jats:italic> showed also significant association with FD<\/jats:styled-content> (2.18 [1.35\u20133.54], 3.46 [1.30\u20139.23], and 2.18 [1.48\u20133.19]). While heterozygous GC <\/jats:styled-content>MIF<\/jats:styled-content><\/jats:italic> genotype was more common in dyspeptics (1.67 [1.07\u20132.60]), homozygous CC<\/jats:styled-content> genotype and the C allele of TRPV<\/jats:styled-content>1<\/jats:italic> gene were more prevalent in controls (0.47 [0.25\u20130.87] and 0.69 [0.51\u20130.92], respectively). None of the gene polymorphism was related either to dyspepsia clinical syndrome type or to the H. pylori<\/jats:italic> infection. Among dyspeptics, CD<\/jats:styled-content>14 <\/jats:italic>TT<\/jats:styled-content> genotype was related to lower epigastric pain burden score (p<\/jats:italic><.011); CD<\/jats:styled-content>14 <\/jats:italic>CT<\/jats:styled-content> genotype was related to higher epigastric burning and nausea burden scores (p<\/jats:italic><.04) while belching score was lower (p<\/jats:italic>=.027) in MIF<\/jats:styled-content><\/jats:italic> CG<\/jats:styled-content> dyspeptics.<\/jats:p><\/jats:sec>Conclusion & Inferences<\/jats:title>Functional dyspepsia susceptibility is related to CD<\/jats:styled-content>14<\/jats:italic>, GNB<\/jats:styled-content>3<\/jats:italic>, MIF<\/jats:styled-content><\/jats:italic>, and TRPV<\/jats:styled-content>1<\/jats:italic> gene polymorphisms, while CD<\/jats:styled-content>14<\/jats:italic> and MIF<\/jats:styled-content><\/jats:italic> gene variants are also associated with dyspepsia symptoms burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12913","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T10:58:23Z","timestamp":1468925903000},"source":"Crossref","is-referenced-by-count":20,"title":["Functional dyspepsia susceptibility is related to CD<\/scp>14<\/i>,GNB<\/scp>3<\/i>,MIF<\/scp><\/i>, and TRPV<\/scp>1<\/i> gene polymorphisms in the Greek population"],"prefix":"10.1111","volume":"29","author":[{"given":"K.","family":"Triantafyllou","sequence":"first","affiliation":[{"name":"Hepatogastroenterology Unit Second Department of Internal Medicine Research institute and Diabetes Center Attikon University General Hospital Medical School National and Kapodistrian University Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kourikou","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit Second Department of Internal Medicine Research institute and Diabetes Center Attikon University General Hospital Medical School National and Kapodistrian University Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gazouli","sequence":"additional","affiliation":[{"name":"Laboratory of Biology Medical School National and Kapodistrian University Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. P.","family":"Karamanolis","sequence":"additional","affiliation":[{"name":"Academic Department of Gastroenterology Laiko General Hospital Medical School National and Kapodistrian University Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. D.","family":"Dimitriadis","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit Second Department of Internal Medicine Research institute and Diabetes Center Attikon University General Hospital Medical School National and Kapodistrian University Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1501505"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.018"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12044"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31818b8ed9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1966-z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12036"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4065\/75.9.907"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06639.x"},{"key":"e_1_2_10_11_1","first-page":"8957","article-title":"Helicobacter pylori and functional dyspepsia: an unsolved issue?","volume":"20","author":"Zullo A","year":"2014","journal-title":"World J Gastroenterol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05128.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.533"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.8.2.8119492"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01837.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-003-0010-4"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/72262"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/421915"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1141"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.03.006"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00481.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01102.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-11-13"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9923-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2012.6.2.223"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.2.205"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.2008015"},{"key":"e_1_2_10_29_1","first-page":"717","article-title":"Genetic polymorphisms of molecules associated with inflammation and immune response in Japanese subjects with functional dyspepsia","volume":"20","author":"Arisawa T","year":"2007","journal-title":"Int J Mol Med"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181b5745e"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309098272"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i5.681"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-45"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1903-0"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl268"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.206"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i25.7672"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01781.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12596"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2014.8.3.271"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000511"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1726-7"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3057-y"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"e_1_2_10_45_1","first-page":"87","article-title":"Healthy control subjects are poorly defined in case\u2010control studies of irritable bowel syndrome","volume":"28","author":"Ghorbani S","year":"2015","journal-title":"Ann Gastroenterol"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12913","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:54:56Z","timestamp":1695495296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,19]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/nmo.12913"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12913","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,19]]},"article-number":"e12913"}}