{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:40:04Z","timestamp":1781851204313,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T00:00:00Z","timestamp":1469923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Society of Gastroenterology","award":["FARE - SNFGE - 2012"],"award-info":[{"award-number":["FARE - SNFGE - 2012"]}]},{"name":"Given Imaging"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Criteria for transient lower esophageal sphincter relaxations (TLESR<\/jats:styled-content>s) are well\u2010defined for Dentsleeve manometry. As high\u2010resolution manometry (HRM<\/jats:styled-content>) is now the gold standard to assess esophageal motility, our aim was to propose a consensus definition of TLESR<\/jats:styled-content>s using HRM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Postprandial esophageal HRM<\/jats:styled-content> combined with impedance was performed in 10 patients with gastroesophageal reflux disease. Transient lower esophageal sphincter relaxations identification was performed by 17 experts using a Delphi process. Four investigators then characterized TLESR<\/jats:styled-content> candidates that achieved 100% agreement (TLESR<\/jats:styled-content> events) and those that achieved less than 25% agreement (non\u2010events) after the third round. Logistic regression and decision tree analysis were used to define optimal diagnostic criteria.<\/jats:p><\/jats:sec>Key Results<\/jats:title>All diagnostic criteria were more frequently encountered in the 57 TLESR<\/jats:styled-content> events than in the 52 non\u2010events. Crural diaphragm (CD<\/jats:styled-content>) inhibition and LES<\/jats:styled-content> relaxation duration >10\u00a0seconds had the highest predictive value to identify TLESR<\/jats:styled-content>. Based on decision tree analysis, reflux on impedance, esophageal shortening, common cavity, upper esophageal sphincter relaxation without swallow and secondary peristalsis were alternate diagnostic criteria.<\/jats:p><\/jats:sec>Conclusion & Inferences<\/jats:title>Using HRM<\/jats:styled-content>, TLESR<\/jats:styled-content> might be defined as LES<\/jats:styled-content> relaxation occurring in absence of swallowing, lasting more than 10\u00a0seconds and associated with CD<\/jats:styled-content> inhibition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12920","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:57:06Z","timestamp":1485737826000},"source":"Crossref","is-referenced-by-count":75,"title":["Validation of criteria for the definition of transient lower esophageal sphincter relaxations using high\u2010resolution manometry"],"prefix":"10.1111","volume":"29","author":[{"given":"S.","family":"Roman","sequence":"first","affiliation":[{"name":"Digestive Physiology Hospices Civils de Lyon and Lyon I University Lyon France"},{"name":"Inserm U1032 LabTAU Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Holloway","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Royal Adelaid Hospital Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Israelitic Hospital University of Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Herbella","sequence":"additional","affiliation":[{"name":"Department of Surgery Escola Paulista de Medicina Federal University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Zerbib","sequence":"additional","affiliation":[{"name":"Gastroenterology CHU Bordeaux and Bordeaux II University Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First affiliated Hospital Sen Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bernard","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon P\u00f4le Information M\u00e9dicale Evaluation Recherche Unit\u00e9 de recherche clinique Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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J.","family":"Kahrilas","sequence":"additional","affiliation":[{"name":"Division of Gasotrenterology Department of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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