{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:26:27Z","timestamp":1790436387341,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,21]],"date-time":"2016-08-21T00:00:00Z","timestamp":1471737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007398","name":"Strategiske Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001825","name":"Styrelsen for Forskning og Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004046","name":"Karen Elise Jensens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sacral nerve stimulation (<jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>) is a well\u2010established treatment for fecal incontinence but its mode of action remains obscure. Anal sphincter function is usually evaluated with manometry but resistance to distension may be a more appropriate parameter than luminal pressure. The functional lumen imaging probe allows detailed description of distension properties of the anal canal. Our objective in this study was to characterize the impact of <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> on distension properties of the anal canal in patients with idiopathic fecal incontinence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 10 women (median age 64 [44\u201379] years) with idiopathic fecal incontinence at baseline and during <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>. The luminal geometry of the anal canal was examined with the <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content> at rest and during squeeze and the distensibility of the anal canal was investigated during filling of the bag.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results<\/jats:title><jats:p>All patients were successfully treated with <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> and the mean Wexner Incontinence Score was reduced from 14.9\u00a0\u00b1\u00a04 to 7.1\u00a0\u00b1\u00a04.8 (<jats:italic>P<\/jats:italic>&lt;.001). The pressure required to open the narrowest point of the anal canal during distension (yield pressure) increased from 14.5\u00a0\u00b1\u00a012.2\u00a0mmHg at baseline to 20.5\u00a0\u00b1\u00a013.3\u00a0mmHg during <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> (<jats:italic>P<\/jats:italic>&lt;.01). The pressure\u2010strain elastic modulus increased non\u2010significantly from 2.2\u00a0\u00b1\u00a00.5 to 2.9\u00a0\u00b1\u00a01.6\u00a0<jats:styled-content style=\"fixed-case\">kP<\/jats:styled-content>a, indicating increased stiffness of the anal canal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and inferences<\/jats:title><jats:p>The yield pressure and the resistance to distension increased in response to <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> for idiopathic fecal incontinence. This will inevitably increase the resistance to flow through the anal canal, which may contribute to the benefits of sacral nerve stimulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12929","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T01:46:40Z","timestamp":1471830400000},"source":"Crossref","is-referenced-by-count":20,"title":["Increased yield pressure in the anal canal during sacral nerve stimulation: a pilot study with the functional lumen imaging probe"],"prefix":"10.1111","volume":"29","author":[{"given":"S.","family":"Haas","sequence":"first","affiliation":[{"name":"Department of Surgery P Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Liao","sequence":"additional","affiliation":[{"name":"GIOME Academia Department of Clinical Medicine Aarhus University  Aarhus 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