{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:31:13Z","timestamp":1753878673687,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,22]],"date-time":"2017-01-22T00:00:00Z","timestamp":1485043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Methusalem grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Endogenous opioids (EO<\/jats:styled-content>) acting on \u03bc\u2010opiod receptors in central and enteric nervous system (ENS<\/jats:styled-content>) control gastrointestinal motility but it is still unclear whetherEO<\/jats:styled-content>inENS<\/jats:styled-content>may control esophageal function in man, thus we will study the effects of methylnaltrexone (MNTX<\/jats:styled-content>), a peripherally selective, and naloxone (NA<\/jats:styled-content>), a non\u2010selective \u03bc\u2010opiod receptor antagonist, on esophageal motility in healthy subjects.<\/jats:p><\/jats:sec>Methods<\/jats:title>FifteenHV<\/jats:styled-content>(6\u00a0M; 34.1\u00a0\u00b1\u00a00.6\u00a0years;BMI<\/jats:styled-content>: 22.1\u00a0\u00b1\u00a00.1\u00a0kg\/m2<\/jats:sup>) underwent three esophageal high\u2010resolution manometry impedance (HR<\/jats:styled-content>iM) studies with 10 saline swallows administered every 30\u00a0minutes: drug was administered after 30\u00a0minutes (MNTX<\/jats:styled-content>subcutaneously\/NA<\/jats:styled-content>or saline intravenously), a solid meal after 90\u00a0minutes; measurements continued for 120\u00a0minutes postprandially.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Methylnaltrexone did not significantly decrease the upper esophageal sphincter (UES<\/jats:styled-content>) percentage of relaxation preprandially (72.5\u00a0\u00b1\u00a05 vs 66.9\u00a0\u00b1\u00a04.6 and 73\u00a0\u00b1\u00a03.8%,ANOVA<\/jats:styled-content>between placebo,MNTX<\/jats:styled-content>andNA<\/jats:styled-content>,P<\/jats:italic>=NS<\/jats:styled-content>) and postprandially (60\u00a0minutes: 68.2\u00a0\u00b1\u00a05.6 vs 61\u00a0\u00b1\u00a05.5 and 67.1\u00a0\u00b1\u00a05.6%; 120\u00a0minutes: 68\u00a0\u00b1\u00a05.9 vs 59.3\u00a0\u00b1\u00a05.2 and 67.7\u00a0\u00b1\u00a04.7%;ANOVA<\/jats:styled-content>between placebo,MNTX<\/jats:styled-content>andNA<\/jats:styled-content>,P<\/jats:italic>=NS<\/jats:styled-content>).MNTX<\/jats:styled-content>andNA<\/jats:styled-content>did not significantly alter preprandial and postprandialLES<\/jats:styled-content>resting pressures and integrated relaxation pressure (ANOVA<\/jats:styled-content>between placebo,MNTX<\/jats:styled-content>andNA<\/jats:styled-content>, allP<\/jats:italic>=NS<\/jats:styled-content>). Peak front velocity and distal contractile integral were not altered pre\u2010 and postprandially byMNTX<\/jats:styled-content>andNA<\/jats:styled-content>(ANOVA<\/jats:styled-content>between placebo,MNTX<\/jats:styled-content>andNA<\/jats:styled-content>,P<\/jats:italic>=NS<\/jats:styled-content>). Transient lower esophageal sphincter relaxations (TLESR<\/jats:styled-content>s\u2019) number was not altered byMNTX<\/jats:styled-content>andNA<\/jats:styled-content>(ANOVA<\/jats:styled-content>between placebo,MNTX<\/jats:styled-content>andNA<\/jats:styled-content>, allP<\/jats:italic>=NS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Conclusions and Inferences<\/jats:title>The peripheral selective and non\u2010selective \u03bc\u2010opioid receptor antagonistsMNTX<\/jats:styled-content>andNA<\/jats:styled-content>, respectively, do not alterTLESR<\/jats:styled-content>s occurrence and esophageal peristalsis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12938","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:26:42Z","timestamp":1485131202000},"source":"Crossref","is-referenced-by-count":13,"title":["Effect of methylnaltrexone and naloxone on esophageal motor function in man"],"prefix":"10.1111","volume":"29","author":[{"given":"E.","family":"Scarpellini","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine University Hospital Gasthuisberg Catholic University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pauwels","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine University Hospital Gasthuisberg Catholic University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Vos","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine University Hospital Gasthuisberg Catholic University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Rommel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine University Hospital Gasthuisberg Catholic University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tack","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine University Hospital Gasthuisberg Catholic University of Leuven Leuven 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