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Symptoms can be non\u2010specific, and result in this condition being diagnosed incorrectly or too late with consequences for morbidity and even mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The present article aims to provide pediatric and adult gastroenterologists with an up to date review about clinical features, diagnosis and therapeutic options for <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content>. Although pediatric and adult <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content> share many clinical aspects distinctive features can be identified. There is no single diagnostic test or pathognomonic finding of <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content>, thus a stepwise approach including radiology, endoscopy, laboratory, manometry, and histopathology should be considered in the diagnostic work\u2010up. Treatment of patients with <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content> is challenging and requires a multidisciplinary effort with participation of appropriately experienced gastroenterologists, pathologists, dieticians, surgeons, psychologists, and other subspecialists based on the presence of comorbidities. Current treatment options invariably involve surgery and specialized nutritional support, especially in children. Medical therapies are mainly aimed to avoid complications such as sepsis or intestinal bacterial overgrowth and, where possible, restore intestinal propulsion. More efficacious therapeutic options are eagerly awaited for such difficult patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12945","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T05:23:07Z","timestamp":1475126587000},"source":"Crossref","is-referenced-by-count":110,"title":["Chronic intestinal pseudo\u2010obstruction in children and adults: diagnosis and therapeutic options"],"prefix":"10.1111","volume":"29","author":[{"given":"G.","family":"Di Nardo","sequence":"first","affiliation":[{"name":"Pediatric Unit Orvieto Hospital  Orvieto Italy"},{"name":"Pediatric Gastroenterology Unit International Hospital Salvator Mundi  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lauro","sequence":"additional","affiliation":[{"name":"Liver and Multiorgan Transplant Unit St. Orsola\u2010Malpighi University Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Stanghellini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Centro di Ricerca BioMedica Applicata (C.R.B.A.) University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Thapar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Great Ormond Street Hospital Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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