{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:31:56Z","timestamp":1760189516492,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["R01 DK78924"],"award-info":[{"award-number":["R01 DK78924"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000135"],"award-info":[{"award-number":["UL1 TR000135"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>While widely used in clinical practice, the reproducibility of high\u2010definition anorectal manometry (HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>) remains unclear. We evaluated the intra\u2010individual reproducibility of HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content> and compared pressures measured with HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content> and high\u2010resolution anorectal manometry (HR<\/jats:styled-content>\u2010ARM<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirty\u2010six women with fecal incontinence had an initial HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content> (HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>1); on the same day, after randomization, 21 had a second (HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>2). Sixteen women had a third (HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>3) 4 weeks later. Twenty\u2010five had also been evaluated by HR<\/jats:styled-content>\u2010ARM<\/jats:styled-content> previously. Rectoanal pressures were assessed at rest, during squeeze and simulated evacuation. Concordance among pressures was assessed with Lin's concordance correlation coefficient (CCC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Key Results<\/jats:title>Anal resting and squeeze pressures measured with HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content> were reproducible on the same and different days; for average resting pressures of HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>1 vs HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>2, CCC<\/jats:styled-content>\u00a0=\u00a00.73 (95% confidence interval [CI<\/jats:styled-content>]: 0.53\u20130.94), and for HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>1 vs HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>3, CCC<\/jats:styled-content>\u00a0=\u00a00.60 (95% CI<\/jats:styled-content>: 0.28\u20130.93). For maximum squeeze pressures of HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>1 vs HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>2, CCC<\/jats:styled-content>\u00a0=\u00a00.86 (95% CI<\/jats:styled-content>: 0.75\u20130.97), and for HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>1 vs HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>3, CCC<\/jats:styled-content>\u00a0=\u00a00.56 (95% CI<\/jats:styled-content>: 0.21\u20130.91). The rectoanal gradient during evacuation was significantly concordant between HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>1 and HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>2 but not HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>1 and HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>3. Resting (CCC<\/jats:styled-content>\u00a0=\u00a00.38 [95% CI<\/jats:styled-content>: 0.14\u20130.62]) and squeeze pressures (CCC<\/jats:styled-content>\u00a0=\u00a00.73 [95% CI<\/jats:styled-content>: 0.57\u20130.89]) measured with HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content>1 and HR<\/jats:styled-content>\u2010ARM<\/jats:styled-content> were also concordant.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>Among women with fecal incontinence, measurements with HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content> were reproducible on the same (anal resting and squeeze pressures and rectoanal gradient during evacuation) and different days (anal resting and squeeze pressures) and correlated with HR<\/jats:styled-content>\u2010ARM<\/jats:styled-content> measurements. These findings support use of HD<\/jats:styled-content>\u2010ARM<\/jats:styled-content> and HR<\/jats:styled-content>\u2010ARM<\/jats:styled-content> for longitudinal assessments of anal resting and squeeze pressures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12950","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T13:10:42Z","timestamp":1475845842000},"source":"Crossref","is-referenced-by-count":19,"title":["Reproducibility of high\u2010definition (3D) manometry and its agreement with high\u2010resolution (2D) manometry in women with fecal incontinence"],"prefix":"10.1111","volume":"29","author":[{"given":"S.","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Clinical and Enteric Neuroscience Translational and Epidemiological Research Program (C.E.N.T.E.R.) Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Feuerhak","sequence":"additional","affiliation":[{"name":"Clinical and Enteric Neuroscience Translational and Epidemiological Research Program (C.E.N.T.E.R.) Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Zinsmeister","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Department of Health Sciences Research Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Bharucha","sequence":"additional","affiliation":[{"name":"Clinical and Enteric Neuroscience Translational and Epidemiological Research Program (C.E.N.T.E.R.) Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2011.09.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.028"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.10.062"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.190"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.013"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.047696"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15168"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01069.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12317"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14025"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.12.034"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.06.035"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(13)60308-X"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.221"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.049"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01782.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2003.00099.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00499.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.06.008"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004230050141"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050417"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800760628"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050212"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12868"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296139"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01700.x"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12950","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12950","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T07:29:08Z","timestamp":1696490948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,2]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/nmo.12950"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12950","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"type":"print","value":"1350-1925"},{"type":"electronic","value":"1365-2982"}],"subject":[],"published":{"date-parts":[[2016,10,2]]},"article-number":"e12950"}}