{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:53:27Z","timestamp":1792101207490,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T00:00:00Z","timestamp":1477353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5T32DK007760\u201017"],"award-info":[{"award-number":["5T32DK007760\u201017"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the well\u2010documented economic and psychosocial burden of irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>), few studies have focused on the impact of <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> on daily activities. This study aims to quantitate impairment in daily activities among <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients and to evaluate the relationship between impairment, <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>, quality of life, and psychiatric symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 179 participants meeting <jats:styled-content style=\"fixed-case\">ROME<\/jats:styled-content>\u2010III criteria for <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> completed an online research survey evaluating the following variables: (i) the impact of <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> on daily activities, (ii) comorbid psychiatric diagnoses, (iii) symptom severity, (iv) quality of life, and (v) symptom\u2010specific cognitive affective factors related to <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>This sample reported a high degree of impairment due to <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>, with 76% of the sample reporting some degree of <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010related impairment in at least five different domains of daily life. Rates of impairment were significantly higher for participants who met criteria for anxiety, depression, and\/or panic disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>This study contributes to existing literature by demonstrating a high level of daily impairment among patients with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>, particularly those who meet criteria for anxiety, depression, and panic disorder. These findings support the importance of integrated psychosocial and medical care for <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients, and highlight the utility of evaluation and intervention for behavioral avoidance\/impairment especially among those who exhibit signs or symptoms of psychiatric diagnoses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12982","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T01:26:45Z","timestamp":1477445205000},"source":"Crossref","is-referenced-by-count":62,"title":["The impact of irritable bowel syndrome on daily functioning: Characterizing and understanding daily consequences of <scp>IBS<\/scp>"],"prefix":"10.1111","volume":"29","author":[{"given":"S.","family":"Ballou","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Beth Israel Deaconess Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Keefer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06120.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12848"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016471923384"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.10.010"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"S17","article-title":"Impairment in work productivity and health\u2010related quality of life in patients with IBS","volume":"11","author":"Dean BB","year":"2005","journal-title":"Am J Manag Care"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01456.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01735.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200410000-00008"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(90)90022-V"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_10_13_1","first-page":"237","article-title":"Rome III: new standard for functional gastrointestinal disorders","volume":"15","author":"Drossman DA","year":"2006","journal-title":"J Gastrointest Liver Dis"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","unstructured":"2010 WE Whitehead DA Drossman Validation of symptom\u2010based diagnostic criteria for irritable bowel syndrome: a critical review 814 820","DOI":"10.1038\/ajg.2010.56"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018838507545"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.06.026"},{"issue":"11","key":"e_1_2_10_17_1","first-page":"839","article-title":"Screening for depression and suicidality in a VA primary care setting: 2 items are better than 1 item","volume":"10","author":"Corson K","year":"2004","journal-title":"Am J Manag Care"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.106580"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2003.11.006"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(03)00072-2"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02007.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199303000-00006"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16484"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.09.2229"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31821fbf44"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002800-200609000-00011"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01303162"},{"key":"e_1_2_10_31_1","first-page":"1127","article-title":"Multicultural considerations in the diagnosis and management of irritable bowel syndrome: a selective summary","volume":"25","author":"Ballou SK","year":"2013","journal-title":"Eur J Gastro Hepatol"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01440.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750153476"}],"container-title":["Neurogastroenterology &amp; 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