{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:37:01Z","timestamp":1767854221890,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Anorectal manometry (ARM<\/jats:styled-content>) is typically preformed in a lateral position. This non\u2010physiological testing position has produced an unexpected negative rectoanal pressure gradient (RAPG<\/jats:styled-content>, i.e. difference between rectal and anal pressure) with normal defecation. This study was designed (i) to study differences in ARM<\/jats:styled-content> parameters between water\u2010perfused and solid\u2010state sensors and between lateral and seated positions and (ii) to investigate the roles of ARM<\/jats:styled-content> parameters in predicting balloon expulsion.<\/jats:p><\/jats:sec>Methods<\/jats:title>ARM<\/jats:styled-content> was performed in 18 healthy volunteers (HV<\/jats:styled-content>) and 60 patients with functional constipation (FC<\/jats:styled-content>) under three randomized conditions: water\u2010perfused in lateral position, solid\u2010state in lateral position, and solid\u2010state in seated position, followed by a balloon expulsion test in seated position.<\/jats:p><\/jats:sec>Key Results<\/jats:title>i) Under the same lateral position, solid\u2010state sensors produced higher rectal resting pressure and RAPG<\/jats:styled-content> than water\u2010perfused sensors. ii) Using the solid\u2010state sensors, ARM<\/jats:styled-content> in the seated position revealed higher resting rectal pressure (34.9 vs 10.9\u00a0mmHg in HV<\/jats:styled-content>, 30.9 vs 10.6\u00a0mmHg in FC<\/jats:styled-content>, both P<\/jats:italic><.001) and higher RAPG<\/jats:styled-content> (22.6 vs \u22126.2\u00a0mmHg in HV<\/jats:styled-content>, 17.1 vs \u22128.1\u00a0mmHg in FC<\/jats:styled-content>, both P<\/jats:italic><.001) than the lateral position. iii) When ARM<\/jats:styled-content> was performed using solid\u2010state sensors in seated position, RAPG<\/jats:styled-content> was predictive of balloon expulsion; using 10\u00a0mmHg as a threshold, RAPG<\/jats:styled-content> could predict balloon expulsion with specificity of 82% and sensitivity 77%.<\/jats:p><\/jats:sec>Conclusions and Inference<\/jats:title>ARM<\/jats:styled-content> performed in a seated position using solid\u2010state sensors seems more accurate in assessing rectal pressure, and the RAPG<\/jats:styled-content> measured under these conditions is predictive of balloon expulsion in FC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12997","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T03:23:28Z","timestamp":1480649008000},"source":"Crossref","is-referenced-by-count":18,"title":["Anorectal manometry: Should it be performed in a seated position?"],"prefix":"10.1111","volume":"29","author":[{"given":"G.\u2010j.","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing China"},{"name":"Division of Gastroenterology Wuxi No.2 Hospital affiliated to Nanjing Medical University Wuxi China"},{"name":"Ningbo Pace Translational Medical Research Center Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Ningbo Yinzhou People's Hospital Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Pasricha","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Johns Hopkins Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D. Z.","family":"Chen","sequence":"additional","affiliation":[{"name":"Ningbo Pace Translational Medical Research Center Ningbo China"},{"name":"Division of Gastroenterology and Hepatology Johns Hopkins Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.028"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03370.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.044"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.05.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0631-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.221"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00827.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.03.013"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1445-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308835"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12208"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9043-0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14025"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.064"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.70"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41845.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.06.004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.10.1049"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2011.09.001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01069.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12628"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12997","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:54:59Z","timestamp":1695506099000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/nmo.12997"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12997","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]},"article-number":"e12997"}}