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We sought to evaluate the effect of bilateral transcutaneous cervical vagal nerve stimulation (t\u2010<jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content>) on validated parameters of autonomic tone and cytokines in 20 healthy subjects. 24\u00a0hours after t\u2010<jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content>, there was an increase in cardiac vagal tone and a reduction in tumor necrosis factor\u2010\u03b1 in comparison to baseline. No change was seen in blood pressure, cardiac sympathetic index or other cytokines. These preliminary data suggest that t\u2010<jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> exerts an autonomic and a subtle antitumor necrosis factor\u2010\u03b1 effect, which warrants further evaluation in larger controlled studies.<\/jats:p>","DOI":"10.1111\/nmo.12999","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T01:11:32Z","timestamp":1481591492000},"source":"Crossref","is-referenced-by-count":85,"title":["Transcutaneous cervical vagal nerve stimulation modulates cardiac vagal tone and tumor necrosis factor\u2010alpha"],"prefix":"10.1111","volume":"29","author":[{"given":"C.","family":"Brock","sequence":"first","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology &amp; Hepatology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Aziz","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience and Trauma Blizard Institute Wingate Institute of Neurogastroenterology Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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