{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:38:19Z","timestamp":1753879099558,"version":"3.41.2"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T00:00:00Z","timestamp":1481500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Erosive reflux disease (<jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content>) is prevalent in the West, and its incidence is increasing in the East. The differences between the West and East, especially in body composition, have not been investigated thoroughly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects who underwent esophagogastroduodenoscopy and body composition analysis during health screening were analyzed retrospectively. Russian Caucasians who visited Korea were propensity matched with native Koreans. Endoscopy results were analyzed to identify <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content> and gastroesophageal flap valve (<jats:styled-content style=\"fixed-case\">GEFV<\/jats:styled-content>) status. Body composition and laboratory results were compared to identify risk factors for <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>32\u00a0279 subjects underwent health screening with 1496 Russian Caucasians propensity matched with 1496 Koreans. <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content> prevalence was 20.2% for Caucasians and 9.8% for Koreans (<jats:italic>P<\/jats:italic>&lt;.001). Caucasians had significantly greater body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and were more sarcopenic. Significant risk factors for <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content> were Caucasian ethnicity (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.629, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.265\u20132.099, <jats:italic>P<\/jats:italic>&lt;.001), male gender (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.374, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.883\u20132.993, <jats:italic>P<\/jats:italic>&lt;.001), greater <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.067, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.041\u20131.093, <jats:italic>P<\/jats:italic>&lt;.001), and abnormal <jats:styled-content style=\"fixed-case\">GEFV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.730, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.194\u20133.397, <jats:italic>P<\/jats:italic>&lt;.001). H. pylori seropositivity (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.614, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.488\u20130.774, <jats:italic>P<\/jats:italic>&lt;.001) and atrophic gastritis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.547, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.411\u20130.728, <jats:italic>P<\/jats:italic>&lt;.001) were significantly preventive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Caucasian ethnicity is a significant risk factor for <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content>. Greater <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, male gender and abnormal <jats:styled-content style=\"fixed-case\">GEFV<\/jats:styled-content> are associated with <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content>, and H. pylori seropositivity and atrophic gastritis are preventive. Further studies are needed to assess the differences in <jats:styled-content style=\"fixed-case\">ERD<\/jats:styled-content> between Caucasians and East Asians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13002","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T01:11:07Z","timestamp":1481591467000},"source":"Crossref","is-referenced-by-count":11,"title":["Russian Caucasians have a higher risk of erosive reflux disease compared with East Asians: A direct endoscopic comparison"],"prefix":"10.1111","volume":"29","author":[{"given":"S.\u2010H.","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. K.","family":"Baeg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine International St. Mary's Hospital Catholic Kwandong University College of Medicine  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. S.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine International St. Mary's Hospital Catholic Kwandong University College of Medicine  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u2010G.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306393"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00723.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.08.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.15.1972"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903183401101"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.03.077"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.3.368"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.1.14"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02455.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04396.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2010.01089.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.03.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318167b88a"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2011.5.3.246"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70006-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609094509"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199904000-00002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.5.1067"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/diaclin.33.2.97"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67402-8"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.11.025"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02165.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02089.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.051821"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(03)00057-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199908000-00006"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01351.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0413-9"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04518.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.109413"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2013.19.3.338"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1690"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355437"},{"key":"e_1_2_8_38_1","first-page":"1","article-title":"WHO Expert Committee on Problems Related to Alcohol Consumption. 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