{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:35:58Z","timestamp":1789133758985,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>General obesity and abdominal obesity is an established risk factor of gastroesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>). However, the influence of weight or waist change on improvement of <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> is unclear. Our aim was to investigate if weight loss or waist reduction improves <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> symptoms and esophagitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective longitudinal study of 15\u00a0295 subjects who underwent gastroscopy for a health checkup and reported <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> symptoms between 2011 and 2013, and repeated a checkup until 2014 was conducted. The improvement of <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> symptoms and esophagitis according to weight loss (\u2265\u22122, \u22120.5 to \u22122\u00a0kg\/m<jats:sup>2<\/jats:sup> in body mass index [<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>]), waist reduction (\u2265\u22125, \u22120.1 to \u22120.5\u00a0cm) and baseline <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\/waist circumference (<jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content>) categories was assessed using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Weight loss or waist reduction was associated with improvement in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> symptoms only in subjects with general or abdominal obesity. Among subjects with general obesity (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> \u226525\u00a0kg\/m<jats:sup>2<\/jats:sup>) and decreased \u22652\u00a0kg\/m<jats:sup>2<\/jats:sup> in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, the adjusted odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) of improvement in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> symptoms was 2.34 (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1.70\u20102.83). Among subjects with abdominal obesity (<jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content> \u226590\u00a0cm) and decreased \u22655\u00a0cm in <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content>, the corresponding <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> was 2.16 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.56\u20102.90). There was no association between weight loss or waist reduction and improvement in esophagitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Weight loss or waist reduction was associated with improvement in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> symptoms only in subjects with general or abdominal obesity. Weight loss or waist reduction will be an important treatment option in obese patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13009","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T23:00:59Z","timestamp":1482361259000},"source":"Crossref","is-referenced-by-count":35,"title":["Weight loss and waist reduction is associated with improvement in gastroesophageal disease reflux symptoms: A longitudinal study of 15\u00a0295 subjects undergoing health checkups"],"prefix":"10.1111","volume":"29","author":[{"given":"S.\u2010K.","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Lee","sequence":"additional","affiliation":[{"name":"Health Screening Center Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010J.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. I.","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ryu","sequence":"additional","affiliation":[{"name":"Center for Cohort Studies Total Healthcare Center Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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