{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:29:52Z","timestamp":1760646592291,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aim of the present study was to investigate whether the baseline impedance (BI<\/jats:styled-content>) value is a useful parameter to evaluate the condition of the esophageal mucosa in neurologically impaired (NI<\/jats:styled-content>) children undergoing multichannel intraluminal impedance pH measurements (pH\/MII<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>The retrospective study included 55 NI<\/jats:styled-content> patients \u226415\u00a0years. The patients were divided into acid gastroesophageal reflux disease (GERD<\/jats:styled-content>), non\u2010acid GERD<\/jats:styled-content> and GERD<\/jats:styled-content> (\u2212) groups. Furthermore, the patients in the acid GERD<\/jats:styled-content> group were subdivided into erosive reflux disease (ERD<\/jats:styled-content>) and non\u2010erosive reflux disease (NERD<\/jats:styled-content>) groups. pH\/MII<\/jats:styled-content> parameters and BI<\/jats:styled-content> values (Z1\u20106) were compared among three groups or between two groups, respectively. A Spearman's correlation analysis was used for the correlation analysis of pH\/MII<\/jats:styled-content> parameters and BI<\/jats:styled-content> values. A receiver operator characteristic curve analysis was used to evaluate the optimum cut\u2010off values of BI<\/jats:styled-content> to discriminate ERD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Key Results<\/jats:title>The BI<\/jats:styled-content> values of the proximal and the distal channels in ERD<\/jats:styled-content> group were significantly lower than those in NERD<\/jats:styled-content> group. The BI<\/jats:styled-content> values of the distal channels demonstrated significant negative correlations with acid exposure related pH\/MII<\/jats:styled-content> parameters. The optimal cut off value of BI<\/jats:styled-content> in the most distal channel was determined to be 1500\u00a0\u03a9.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>The present study suggested that NI<\/jats:styled-content> children with reflux esophagitis were likely to suffer mucosal damage up to the proximal esophagus and cut\u2010off BI<\/jats:styled-content> values may help estimate the presence of reflux esophagitis. Baseline impedance is a potent parameter, reflecting the esophageal mucosal damage in NI<\/jats:styled-content> children who have difficulty in undergoing endoscopic examinations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13012","type":"journal-article","created":{"date-parts":[[2017,1,14]],"date-time":"2017-01-14T01:08:10Z","timestamp":1484356090000},"source":"Crossref","is-referenced-by-count":9,"title":["A baseline impedance analysis in neurologically impaired children: A potent parameter for estimating the condition of the esophageal mucosa"],"prefix":"10.1111","volume":"29","author":[{"given":"S.","family":"Fukahori","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Kurume University School of Medicine Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Kurume University School of Medicine Kurume Fukuoka 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