{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T01:47:19Z","timestamp":1766627239716,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,29]],"date-time":"2017-01-29T00:00:00Z","timestamp":1485648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Multiple water swallow is increasingly used as a complementary challenge test in patients undergoing high\u2010resolution manometry (<jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>). Our aim was to establish the range of normal pressure responses during the rapid drink challenge test in a large population of healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pressure responses to a rapid drink challenge test (100 or 200\u00a0mL of water) were prospectively analyzed in 105 healthy subjects studied in nine different hospitals from different countries. Esophageal motility was assessed in all subjects by solid\u2010state <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>. In 18 subjects, bolus transit was analyzed using concomitant intraluminal impedance monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>A virtually complete inhibition of pressure activity was observed during multiple swallow: Esophageal body pressure was above 20\u00a0mm Hg during 1 (0\u20108) % and above 30\u00a0mm Hg during 1 (0\u20105) % of the swallow period, and the pressure gradient across the esophagogastric junction was low (\u22121 (\u22127 to 4) mm Hg). At the end of multiple swallow, a postswallow contraction was evidenced in only 50% of subjects, whereas the remaining 50% had non\u2010transmitted contractions. Bolus clearance was completed after 7 (1\u201030) s after the last swallow, as evidenced by multichannel intraluminal impedance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>The range of normal pressure responses to a rapid drink challenge test in health has been established in a large multicenter study. Main responses are a virtually complete inhibition of esophageal pressures with a low\u2010pressure gradient across esophagogastric junction. This data would allow the correct differentiation between normal and disease when using this test.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13021","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T02:43:01Z","timestamp":1485744181000},"source":"Crossref","is-referenced-by-count":41,"title":["Normal values of esophageal pressure responses to a rapid drink challenge test in healthy subjects: results of a multicenter study"],"prefix":"10.1111","volume":"29","author":[{"given":"I.","family":"Marin","sequence":"first","affiliation":[{"name":"Motility and Functional Gut Disorders Unit University Hospital Germans Trias i Pujol Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Department of Medicine Autonomous University of Barcelona  Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Cisternas","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Alemana de Santiago Facultad de Medicina Universidad del Desarrollo  Santiago de Chile Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Abrao","sequence":"additional","affiliation":[{"name":"University Hospital Clementino Fraga Filho  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lemme","sequence":"additional","affiliation":[{"name":"University Hospital Clementino Fraga Filho  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bilder","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u2013 Escuela de Medicina Fundaci\u00f3n Favaloro  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ditaranto","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u2013 Escuela de Medicina Fundaci\u00f3n Favaloro  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Coello","sequence":"additional","affiliation":[{"name":"Axxis Hospital  Quito Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hani","sequence":"additional","affiliation":[{"name":"San Ignacio Hospital Pontificia Universidad Javeriana  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Leguizamo","sequence":"additional","affiliation":[{"name":"San Ignacio Hospital Pontificia Universidad Javeriana  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Meixueiro","sequence":"additional","affiliation":[{"name":"Veracruzana University  Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Remes\u2010Troche","sequence":"additional","affiliation":[{"name":"Veracruzana University  Veracruz Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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