{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:32:35Z","timestamp":1788370355534,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Flanders Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Rome III criteria subdivide functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) in the epigastric pain syndrome (<jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>) and the postprandial distress syndrome (<jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>) based on the frequency of the symptoms to optimize the diagnostic and therapeutic approach. However, it is unclear to which extent the frequency of the symptoms is related to their severity. Our aim was to explore the frequency and severity of dyspeptic symptoms and their relationship in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Functional dyspepsia patients fulfilling the Rome III diagnostic completed a questionnaire that evaluated the frequency and severity of <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> symptoms. The concordance between the severity and frequency categories was analyzed by means of spearman correlation and the concordance correlation coefficient (\u03c1<jats:sub>c<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>In the entire patient cohort (<jats:italic>n<\/jats:italic>=421), the classification of symptoms severity and frequency showed good concordance for all symptoms. In the <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content> subgroup (<jats:italic>n<\/jats:italic>=\u2026.), the symptom severity and frequency score of epigastric pain showed a poor correlation (<jats:italic>r<\/jats:italic>=.28; \u03c1<jats:sub>c<\/jats:sub>=0.07). The <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> subgroup (<jats:italic>n<\/jats:italic>=\u2026) showed a good correlation for most of the symptoms. Due to its limited occurrence in this group, the correlation of the severity and frequency scores for epigastric pain is of little relevance (<jats:italic>r<\/jats:italic>=.79; \u03c1<jats:sub>c<\/jats:sub>=0.58). The overlap <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> group showed good correlation for most of the symptoms, except for epigastric pain (pain <jats:italic>r<\/jats:italic>=.24; \u03c1<jats:sub>c<\/jats:sub>=0.09).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>We conclude that the information given by the assessment of frequency and severity of <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> symptoms is comparable and hence one of the scores sufficiently identifies symptom pattern in <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> patients. In <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content> patients, both the symptom frequency and severity should be taken into account as two separate entities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13024","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T16:26:08Z","timestamp":1489508768000},"source":"Crossref","is-referenced-by-count":18,"title":["Rome III functional dyspepsia symptoms classification: Severity vs frequency"],"prefix":"10.1111","volume":"29","author":[{"given":"F.","family":"Carbone","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) KULeuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Holvoet","sequence":"additional","affiliation":[{"name":"Gastroenterology University Hospital Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Vanuytsel","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) KULeuven  Leuven Belgium"},{"name":"Gastroenterology University Hospital Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tack","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) KULeuven  Leuven Belgium"},{"name":"Gastroenterology University Hospital Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.14"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01262.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.11"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000121347"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12585"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01859.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01939.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1022-3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-9567-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00348-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01706.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04640.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-8-199304150-00009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.69"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00445.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12355"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01363.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.136"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04078.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:QURE.0000021689.86296.e4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.128"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13753"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12381"}],"container-title":["Neurogastroenterology &amp; 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