{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:40:07Z","timestamp":1782826807863,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,12]],"date-time":"2017-02-12T00:00:00Z","timestamp":1486857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>A link between small intestinal bacterial overgrowth (SIBO<\/jats:styled-content>) and celiac disease (CD<\/jats:styled-content>) has been hypothesized.<\/jats:p><\/jats:sec>Methods<\/jats:title>Literature search was performed in main medical databases. Methods of analysis\/inclusion criteria were based on Preferred Reporting Items for Systematic reviews and Meta\u2010Analyses recommendations. The end\u2010point was to estimate, by a pooled\u2010data analysis, SIBO<\/jats:styled-content> prevalence in CD<\/jats:styled-content>. Proportions\/percentages and their 95% confidence intervals (CI<\/jats:styled-content>) were calculated by inverse variance method, whereas odd ratios (OR<\/jats:styled-content>) and their 95% CI<\/jats:styled-content> were estimated, where available, based on the Mantel\u2010Haenszel method. Data were entered into the RevMan 5.3 software.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Eleven articles fulfilled considered criteria. The pooled mean prevalence of SIBO<\/jats:styled-content> in CD<\/jats:styled-content> was 20% (95% CI<\/jats:styled-content> of 10%\u201030%). In comparison to asymptomatic controls, CD<\/jats:styled-content> was associated to higher risk of SIBO<\/jats:styled-content>, with an OR<\/jats:styled-content> of 10.52 (95% CI<\/jats:styled-content> 2.69\u201041.21, P<\/jats:italic>=.0007). Jejunal aspirate culture assessed SIBO<\/jats:styled-content> prevalence of 11% (95% CI<\/jats:styled-content> 3%\u201019%) in CD<\/jats:styled-content>, whereas breath tests detected a higher value (23%, 95% CI<\/jats:styled-content> 10%\u201037%). The pooled prevalence of SIBO<\/jats:styled-content> in CD<\/jats:styled-content> patients who were symptomatic despite a GFD<\/jats:styled-content> was 28% (95% CI<\/jats:styled-content> 10%\u201047%), higher than in asymptomatic celiac patients (pooled prevalence of 10%, with a 95% CI<\/jats:styled-content> of 3%\u201016%), despite not statistically significant (P<\/jats:italic>=.06). When GFD<\/jats:styled-content>\u2010unresponsive CD<\/jats:styled-content> was defined only by clinical persistence of symptoms, the prevalence of SIBO<\/jats:styled-content> was higher than in the case of villous atrophy association (31% vs 16% P<\/jats:italic>=.33).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The heterogeneity of available studies may not support a relationship SIBO<\/jats:styled-content>\u2010CD<\/jats:styled-content>. Nevertheless, SIBO<\/jats:styled-content> could be more common in CD<\/jats:styled-content> when symptoms do not improve after GFD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13028","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T03:46:42Z","timestamp":1486957602000},"source":"Crossref","is-referenced-by-count":37,"title":["Small intestinal bacterial overgrowth and celiac disease: A\u00a0systematic review with pooled\u2010data analysis"],"prefix":"10.1111","volume":"29","author":[{"given":"G.","family":"Losurdo","sequence":"first","affiliation":[{"name":"Section of Gastroenterology Department of Emergency and Organ Transplantation AOU Consorziale Policlinico di Bari University of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Marra","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology Department of Emergency and Organ Transplantation AOU Consorziale 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