{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:13:32Z","timestamp":1791918812146,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n 3D\u2010high definition anorectal manometry (3\n DARM<\/jats:styled-content>\n ) may aid the diagnosis of functional anorectal disorders, but data comparing asymptomatic and symptomatic subjects are scarce. We aimed to describe 3\n DARM<\/jats:styled-content>\n values in asymptomatic volunteers and those with fecal incontinence (\n FI<\/jats:styled-content>\n ) or chronic constipation (\n CC<\/jats:styled-content>\n ), and identify which variables differentiate best these groups.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Asymptomatic subjects were stratified by sex, age, and parity. Those with\n FI<\/jats:styled-content>\n or\n CC<\/jats:styled-content>\n were included according to anorectal symptom questionnaires. Endoanal ultrasound examination and 3\n DARM<\/jats:styled-content>\n were performed the same day. Anal pressures were analyzed at rest, during voluntary squeeze, and during push maneuver, and compared between the 3 groups. Anal pressure defects were defined and compared to ultrasound defects.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n A total of 126 subjects (113 female, mean age 52\u00a0years, range 18\u201083) were included; 36 asymptomatic, 38\n FI<\/jats:styled-content>\n , 42\n CC<\/jats:styled-content>\n . Anal resting and squeeze pressures, and rectal sensitivity values were lower in\n FI<\/jats:styled-content>\n women than in the other groups. Typical anal sphincter asymmetry during squeezing was less frequently observed in\n FI<\/jats:styled-content>\n women. A dyssynergic pattern during push maneuver was found in 70% of asymptomatic subjects, and with a similar frequency in the 2 symptomatic groups. There was slight concordance between 3D\u2010pressure defects and ultrasound defects.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n 3D anal pressures in asymptomatic women were significantly lower than in men, and in\n FI<\/jats:styled-content>\n compared to asymptomatic women. The classical dyssynergic pattern during push maneuver was found as frequently in asymptomatic and symptomatic patients. Further studies should try to identify 3\n DARM<\/jats:styled-content>\n variables that could reliably identify dyssynergic defecation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.13049","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T03:36:39Z","timestamp":1488425799000},"source":"Crossref","is-referenced-by-count":59,"title":["3D High\u2010definition anorectal manometry: Values obtained in asymptomatic volunteers, fecal incontinence and chronic constipation. Results of a prospective multicenter study (\n NOMAD<\/scp>\n )"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2908-1591","authenticated-orcid":false,"given":"F.","family":"Mion","sequence":"first","affiliation":[{"name":"Exploration Fonctionnelle Digestive Hospital Edouard Herriot Hospices Civils de Lyon Lyon I University, and INSERM 1032 LabTAU Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Garros","sequence":"additional","affiliation":[{"name":"Exploration Fonctionnelle Digestive Hospital Edouard Herriot Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-6301","authenticated-orcid":false,"given":"C.","family":"Brochard","sequence":"additional","affiliation":[{"name":"Digestive Physiology and Gastroenterology Pontchaillou Hospital CHU de Rennes Rennes 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