{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:13:46Z","timestamp":1789193626803,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Obesity is an emerging risk factor for fecal incontinence (FI<\/jats:styled-content>). The aim of this study was to characterize pathophysiologic mechanisms of FI<\/jats:styled-content> in obese patients compared with non\u2010obese patients in a prospective case\u2010matched study.<\/jats:p><\/jats:sec>Methods<\/jats:title>The general characteristics and data of the anorectal manometry and endosonography of patients who were evaluated for FI<\/jats:styled-content> at a single institution from 2005 to 2015 were prospectively assessed. Fecal incontinence was defined by a Cleveland Clinic Incontinence Score (CCIS<\/jats:styled-content>) >4. Obesity was defined by a body mass index \u226530\u00a0kg\/m2<\/jats:sup>. Obese patients were case\u2010matched with two age\u2010 and sex\u2010matched non\u2010obese patients.<\/jats:p><\/jats:sec>Key Results<\/jats:title>A total of 201 patients were included (67 obese matched with 134 non\u2010obese). The CCIS<\/jats:styled-content>, Knowles\u2010Eccersley\u2010Scott Symptom Constipation Score and quality of life score were comparable between obese and non\u2010obese patients with FI<\/jats:styled-content>. Factors significantly associated with obesity in FI<\/jats:styled-content> patients were cholecystectomy (odds ratio [OR<\/jats:styled-content>]=3.45 [1.19\u201010.32], P<\/jats:italic>=.0230), irritable bowel syndrome \u2010 diarrhea (OR<\/jats:styled-content>=2.94 [1.22\u20107.19], P<\/jats:italic>=.0158), upper part of the anal canal resting pressure \u226522\u00a0mm\u00a0Hg (OR<\/jats:styled-content>=3.45 [1.45\u20108.76], P<\/jats:italic>=.0045), maximum rectal tolerable volume \u2265240\u00a0mL (OR<\/jats:styled-content>=3.14 [1.34\u20107.54], P<\/jats:italic>=.0082), and abdominal pressure \u226528\u00a0mm\u00a0Hg (OR<\/jats:styled-content>=2.75 [1.13\u20107.33], P<\/jats:italic>=.0248) by multivariate analysis.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>Obese patients with FI<\/jats:styled-content> had a comparable severity of FI<\/jats:styled-content> to that of non\u2010obese patients with FI<\/jats:styled-content>. Regarding obesity in patients with FI<\/jats:styled-content>, physicians should focus on stool consistency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13051","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T08:24:55Z","timestamp":1487838295000},"source":"Crossref","is-referenced-by-count":26,"title":["Pathophysiology of fecal incontinence in obese patients: A prospective case\u2010matched study of 201 patients"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-6301","authenticated-orcid":false,"given":"C.","family":"Brochard","sequence":"first","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"},{"name":"Services d'Explorations Fonctionnelles Digestives CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"},{"name":"INSERM U991 Universit\u00e9 de Rennes 1 Rennes France"},{"name":"CIC 1414 INPHY Universit\u00e9 de Rennes 1 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