{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:32:38Z","timestamp":1760189558276,"version":"3.41.2"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"United States Public Health Service","award":["R01 DC00646"],"award-info":[{"award-number":["R01 DC00646"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The esophagogastric junction (EGJ<\/jats:styled-content>) is a complex sphincter composed of both the crural diaphragm (CD<\/jats:styled-content>) and lower esophageal sphincter (LES<\/jats:styled-content>). Three dimensional high\u2010resolution manometry (3D\u2010HRM<\/jats:styled-content>) provides a dynamic 360\u00b0 representation of EGJ<\/jats:styled-content> pressure in which the CD<\/jats:styled-content> has a distinct pressure signature. We aimed to develop 3D\u2010HRM<\/jats:styled-content> metrics to: (i) quantify the vigor of CD<\/jats:styled-content> contractility, (ii) best eliminate the CD<\/jats:styled-content> contribution and thereby isolate the LES<\/jats:styled-content> component of EGJ<\/jats:styled-content> contractility, and (iii) compare these metrics with conventional HRM<\/jats:styled-content> metric of EGJ<\/jats:styled-content> contractility.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty healthy subjects underwent 3D\u2010HRM<\/jats:styled-content> studies. Two novel 3D\u2010HRM EGJ<\/jats:styled-content> metrics, 3D\u2010DHA<\/jats:sub><\/jats:styled-content>, and 3D\u2010LES<\/jats:styled-content> pressure (3D\u2010LESP<\/jats:styled-content>) were devised and calculated to best approximate the CD<\/jats:styled-content> and LES<\/jats:styled-content> components of the composite EGJ<\/jats:styled-content> pressure topography. These values were then compared to conventional HRM<\/jats:styled-content> metrics of EGJ<\/jats:styled-content> contractility, the EGJ<\/jats:styled-content> contractile integral (EGJ<\/jats:styled-content>\u2010CI<\/jats:styled-content>), inspiratory EGJ<\/jats:styled-content> pressure and expiratory EGJ<\/jats:styled-content> pressure.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Mean 3D\u2010DHA<\/jats:sub><\/jats:styled-content> correlated most strongly with EGJ<\/jats:styled-content>\u2010CI<\/jats:styled-content> (r=.82, P<\/jats:italic><.001), while the 3D\u2010LESP<\/jats:styled-content> correlated most strongly with inspiratory EGJ<\/jats:styled-content> pressure (r=.91 P<\/jats:italic><.001) and expiratory EGJ<\/jats:styled-content> pressure (r=.85, P<\/jats:italic><.001).<\/jats:p><\/jats:sec>Conclusions & inferences<\/jats:title>We devised novel 3D\u2010HRM<\/jats:styled-content> metrics to quantify the CD<\/jats:styled-content> (3D\u2010DHA<\/jats:sub><\/jats:styled-content>) and LES<\/jats:styled-content> (3D\u2010LESP<\/jats:styled-content>) elements of EGJ<\/jats:styled-content> contractility. Both measures correlated strongly with conventional HRM<\/jats:styled-content> metrics of EGJ<\/jats:styled-content> contractility. The 3D\u2010DHA<\/jats:sub><\/jats:styled-content>, in particular, correlated strongly with the EGJ<\/jats:styled-content>\u2010CI<\/jats:styled-content> suggesting that both are largely determined by CD<\/jats:styled-content> contractility. It is hoped that future studies will show these new metrics useful in quantifying elements of the antireflux barrier in mechanistically defined subsets of gastro\u2010esophageal reflux disease (GERD) patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13054","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T17:53:54Z","timestamp":1491414834000},"source":"Crossref","is-referenced-by-count":11,"title":["Novel 3D high\u2010resolution manometry metrics for quantifying esophagogastric junction contractility"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-6952","authenticated-orcid":false,"given":"Zhiyue","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medicine The Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinglian","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Pandolfino","sequence":"additional","affiliation":[{"name":"Department of Medicine The Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minhu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology First Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Kahrilas","sequence":"additional","affiliation":[{"name":"Department of Medicine The Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12267"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12638"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12389"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12757"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01733.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12168"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01795.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00063.2012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12500"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:50:33Z","timestamp":1695502233000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,5]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/nmo.13054"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13054","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"type":"print","value":"1350-1925"},{"type":"electronic","value":"1365-2982"}],"subject":[],"published":{"date-parts":[[2017,4,5]]},"article-number":"e13054"}}