{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:02:14Z","timestamp":1773079334059,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novartis Healthcare Pvt. Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transient lower esophageal sphincter relaxations (<jats:styled-content style=\"fixed-case\">TLESR<\/jats:styled-content>s) induced by gastric distension are modulated by the metabotropic glutamate receptor 5 (<jats:styled-content style=\"fixed-case\">mG<\/jats:styled-content>luR5) that influences the vagal reflex loop. We therefore aimed to examine the effects of the selective <jats:styled-content style=\"fixed-case\">mG<\/jats:styled-content>luR5 antagonist mavoglurant (<jats:styled-content style=\"fixed-case\">AFQ<\/jats:styled-content>056) on the number of <jats:styled-content style=\"fixed-case\">TLESR<\/jats:styled-content>s in dogs and reflux episodes in patients with gastroesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a dog model, the number of meal\u2010induced <jats:styled-content style=\"fixed-case\">TLESR<\/jats:styled-content>s was determined after intravenous (0.03, 0.1, 0.3, and 1\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) and oral (1, 3, and 10\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) doses of mavoglurant with reference to vehicle.<\/jats:p><jats:p>In a multicenter, randomized, double\u2010blind, placebo\u2010controlled, three\u2010period crossover study, the incidence of meal\u2010induced reflux episodes was assessed by esophageal impedance monitoring after single, oral doses of mavoglurant (50 and 400\u00a0mg) or baclofen (40\u00a0mg) in 30 patients with moderate to severe <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>In dogs, mavoglurant reduced the number of <jats:styled-content style=\"fixed-case\">TLESR<\/jats:styled-content>s after intravenous and oral administration. In patients with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>, the incidence of postprandial reflux episodes was significantly lower at a dose of 400\u00a0mg mavoglurant (\u221237.5% ; 90% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: \u221257.8, \u221217.2), whereas there was no significant difference at 50\u00a0mg of mavoglurant compared to placebo. A significantly lower incidence of reflux episodes was also noted with the active comparator baclofen (\u221250.3%; 90% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u221266.2, \u221234.3), thereby validating this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>These data suggest a potential clinical benefit of <jats:styled-content style=\"fixed-case\">mG<\/jats:styled-content>luR5 antagonists such as mavoglurant in patients with <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>, particularly in those with persisting symptoms despite treatment with proton pump inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13058","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T11:49:06Z","timestamp":1490356146000},"source":"Crossref","is-referenced-by-count":15,"title":["The selective metabotropic glutamate receptor 5 antagonist mavoglurant (<scp>AFQ<\/scp>056) reduces the incidence of reflux episodes in dogs and patients with moderate to severe gastroesophageal reflux disease"],"prefix":"10.1111","volume":"29","author":[{"given":"M.\u2010L.","family":"Rouzade\u2010Dominguez","sequence":"first","affiliation":[{"name":"Novartis Institutes for Biomedical Research Novartis Pharma AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Pezous","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research Novartis Pharma AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. J.","family":"David","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research Novartis Pharma AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Tutuian","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsspital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bruley des Varannes","sequence":"additional","affiliation":[{"name":"CHU\u2010H\u00f4tel Dieu Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tack","sequence":"additional","affiliation":[{"name":"University Hospitals Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Malfertheiner","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010D.","family":"Allescher","sequence":"additional","affiliation":[{"name":"Klinikum Garmisch\u2010Partenkirchen  Garmisch\u2010Partenkirchen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6637-4406","authenticated-orcid":false,"given":"M.","family":"Ufer","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research Novartis Pharma AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"R\u00fchl","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research Novartis Pharma AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304269"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/653989","article-title":"Current advances in the diagnosis and treatment of nonerosive reflux disease","volume":"653989","author":"Chen CL","year":"2013","journal-title":"Gastroenterol Res Pract"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/983653","article-title":"Current pharmacological management of gastroesophageal reflux disease","volume":"983653","author":"Wang YK","year":"2013","journal-title":"Gastroenterol Res Pract"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.4.270"},{"key":"e_1_2_11_6_1","first-page":"434","article-title":"Medical therapy of gastroesophageal reflux disease","volume":"23","author":"Coron E","year":"2007","journal-title":"Curr Opin Gastroenterol"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.2.386"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i27.4386"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03281.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12644"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0102-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01250.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2010.00418.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.06.069"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32833ae2be"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05081.x"},{"key":"e_1_2_11_17_1","first-page":"G128","article-title":"Criteria for objective definition of transient lower esophageal sphincter relaxation","volume":"268","author":"Holloway RH","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2212-0971(13)70046-3"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01300382"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8698230"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.07.007"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1999.00141.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70400-2"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00528-8"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01907-6"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01394.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.1.19"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.050716"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.4.464"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70408-2"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.10.1397"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2014.20.1.6"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25561"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab4109"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:50:31Z","timestamp":1695502231000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,23]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/nmo.13058"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13058","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,23]]},"article-number":"e13058"}}