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Accumulating evidence suggests the crucial role of central nervous system in the development and maintenance of FD<\/jats:styled-content>. In particular, periaqueductal gray (PAG<\/jats:styled-content>) has demonstrated an important role in modulation of pain and emotion, which may be related to FD<\/jats:styled-content>. However, the study of the PAG<\/jats:styled-content> in FD<\/jats:styled-content> is still limited. This study aimed to assess intrinsic connectivity of the PAG<\/jats:styled-content> in FD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Resting\u2010state functional magnetic imaging (fMRI<\/jats:styled-content>) data were collected from 66 FD<\/jats:styled-content> patients and 42 healthy controls (HC<\/jats:styled-content>s). Functional connectivity analysis was performed to investigate the PAG<\/jats:styled-content> connectivity pattern differences between the patients and HC<\/jats:styled-content>s. We then examined the relationships between functional connectivity within the PAG<\/jats:styled-content> networks and FD<\/jats:styled-content> symptoms.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Compared to HC<\/jats:styled-content>s, patients had increased PAG<\/jats:styled-content> connectivity with the insula, and decreased PAG<\/jats:styled-content> connectivity with the orbitofrontal cortex (OFC<\/jats:styled-content>), dorsolateral prefrontal cortex (dlPFC<\/jats:styled-content>) and hippocampus\/parahippocampus (HIPP<\/jats:styled-content>\/paraHIPP<\/jats:styled-content>). There were positive correlations between disease duration and PAG<\/jats:styled-content> connectivity with the putamen and supplementary motor area (SMA<\/jats:styled-content>), and positive correlations between symptom severity and PAG<\/jats:styled-content> connectivity with the insula. FD<\/jats:styled-content> patients with high level of anxiety and depression had altered PAG<\/jats:styled-content> connectivity with the anterior cingulate cortex (ACC<\/jats:styled-content>), precuneus, dlPFC<\/jats:styled-content> and caudate, compared to other patients.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>These findings indicate that abnormal intrinsic network of the PAG<\/jats:styled-content> might be associated with abnormality of pain processing and disruption of emotion processing in FD<\/jats:styled-content> patients. Our study further complements neuroimaging findings about FD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13060","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T15:48:17Z","timestamp":1490370497000},"source":"Crossref","is-referenced-by-count":21,"title":["Disrupted intrinsic connectivity of the periaqueductal gray in patients with functional dyspepsia: A resting\u2010state fMRI study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6965-8001","authenticated-orcid":false,"given":"P.","family":"Liu","sequence":"first","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"},{"name":"Engineering Research Center of Molecular and NeuroImaging Ministry of Education Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Wang","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"},{"name":"Engineering Research Center of Molecular and NeuroImaging Ministry of Education Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"},{"name":"Engineering Research Center of Molecular and NeuroImaging Ministry of Education Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Zeng","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Lin","sequence":"additional","affiliation":[{"name":"The Mind Research Network Albuquerque NM USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Yang","sequence":"additional","affiliation":[{"name":"Life Science Research Center School of Life Science and Technology Xidian University Xi'an China"},{"name":"Engineering Research Center of Molecular and NeuroImaging Ministry of Education Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Liang","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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