{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:26:28Z","timestamp":1790436388160,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Leuven Unversity"},{"name":"Flanders Research Foundation (FWO)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Laparoscopic Nissen fundoplication is a commonly performed antireflux surgery, after which reflux symptoms are well controlled, however, complications such as inability to belch or dyspeptic symptoms (mimicking those of functional dyspepsia [<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>]) might occur. The aim of the study was to prospectively evaluate symptom pattern and underlying pathophysiological mechanisms in patients with post\u2010Nissen dyspepsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four patients (12\u00a0f, mean age 44.5\u00b12.8\u00a0years) with post\u2010Nissen dyspepsia symptoms, five patients (3\u00a0f, mean age 38.8\u00b13.2\u00a0years) with post\u2010Nissen dysphagia symptoms and 14 pre\u2010fundoplication patients (3\u00a0f, mean age 42.1\u00b12.5\u00a0years) were evaluated. Patients filled out a Rome II\u2010based dyspepsia symptom severity score, performed a gastric emptying test, and a gastric barostat study was used to evaluate the function of the proximal stomach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Upper abdominal bloating scores were higher in post\u2010Nissen dyspepsia patients (<jats:italic>P<\/jats:italic>=.016) and symptoms of postprandial distress syndrome (<jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>) were more present in post\u2010Nissen dyspepsia patients compared to the other two groups (<jats:italic>P<\/jats:italic>=.07). Weight loss was significantly higher in the post\u2010Nissen groups compared to the pre\u2010fundoplication (<jats:italic>P<\/jats:italic>=.02). Gastric emptying rates were similar in the three groups. Gastric accommodation (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>) was significantly impaired in the post\u2010Nissen dyspepsia group (dyspepsia \u221230[\u221286\u201083] vs dysphagia 163[148\u2010203] vs pre\u2010fundoplication 147[75\u2010174]\u00a0mL, <jats:italic>P<\/jats:italic>=.004) and the prevalence of patients with impaired <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> was higher in the post\u2010Nissen group (<jats:italic>P<\/jats:italic>=.007). Postprandial fullness was more prevalent in patients with impaired <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> compared to those with normal <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> (<jats:italic>P<\/jats:italic>=.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Interferences<\/jats:title><jats:p>Patients with post\u2010Nissen dyspepsia show a symptom pattern similar to that in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>, and the main underlying mechanism seems to be impaired gastric accommodation to a meal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13063","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T08:13:09Z","timestamp":1489997589000},"source":"Crossref","is-referenced-by-count":21,"title":["Severely impaired gastric accommodation is a hallmark of post\u2010Nissen functional dyspepsia symptoms"],"prefix":"10.1111","volume":"29","author":[{"given":"A.","family":"Pauwels","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Boecxstaens","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Broers","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-6704","authenticated-orcid":false,"given":"J. 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