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The management of this disease is less than satisfying given complexity of patient presentation and suboptimal diagnostic testing when employed for those poorly responsive to acid suppressive therapy. In this mini review, we discuss some new strategies employed for patients with suspected <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> to better understand disease pathophysiology. We compare the strategies and outline a clinically relevant approach in this difficult group of patients.<\/jats:p>","DOI":"10.1111\/nmo.13065","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T16:29:44Z","timestamp":1492532984000},"source":"Crossref","is-referenced-by-count":1,"title":["Does my patient still have reflux when ppi therapy does not work?"],"prefix":"10.1111","volume":"29","author":[{"given":"M. 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