{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T22:25:52Z","timestamp":1768775152513,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with Barrett's esophagus (<jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>) usually have severe gastroesophageal reflux. However, they often have surprisingly few reflux symptoms. We hypothesized that <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> patients are less sensitive to acid than gastroesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>) patients without Barrett and that this is due to an unusual preservation of mucosal integrity of the squamous epithelium prohibiting transepithelial acid diffusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively analyzed esophageal sensitivity and esophageal mucosal integrity in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients with and without <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> and healthy subjects. An acid perfusion test was performed and mucosal integrity was assessed in vivo by electrical tissue impedance spectroscopy and ex vivo by Ussing chamber experiments with biopsy specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Gastroesophageal reflux disease patients with <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> were less sensitive to acid than <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients without <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>, but more sensitive to acid than healthy controls (time to perception Barrett's 14.0\u00a0minutes, <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> 4.6\u00a0minutes, controls 17.5\u00a0minutes). However, extracellular impedance (6.2 and 5.7 vs 8.4\u00d710<jats:sup>3<\/jats:sup>\u00a0\u03a9\/m) and transepithelial resistance (94.0 and 89 vs 118 \u03a9\/cm<jats:sup>2<\/jats:sup>) was similar in <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients and significantly lower than in healthy subjects. Transepithelial fluorescein flux was equally increased in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients with and without <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> (1.6 and 1.7\u00d710<jats:sup>3<\/jats:sup> vs 0.6\u00d710<jats:sup>3<\/jats:sup>\u00a0nmol\/cm<jats:sup>2<\/jats:sup>\/h).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Esophageal hypersensitivity to acid is less pronounced in <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> patients than in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients without Barrett. However, mucosal integrity of the squamous epithelium is equally impaired in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients with and without Barrett, indicating that factors other than esophageal mucosal barrier integrity explain the difference in acid sensitivity between those with <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> and those without.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13066","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T06:32:51Z","timestamp":1490855571000},"source":"Crossref","is-referenced-by-count":19,"title":["Esophageal sensitivity to acid in patients with Barrett's esophagus is not related to preserved esophageal mucosal integrity"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0603-934X","authenticated-orcid":false,"given":"P. W.","family":"Weijenborg","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. P. M.","family":"Smout","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. K.","family":"Krishnadath","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G. H. M.","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Verheij","sequence":"additional","affiliation":[{"name":"Department of Pathology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds181"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07454.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01306.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06062.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)02589-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.030"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.053"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)33854-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198702000-00006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07543.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i4.514"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302645"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00345.2013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12106"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.174"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70014-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181c8fc83"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(58)80023-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.1.7"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2050.2003.00328.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.276"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.141804"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.13066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.13066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:50:13Z","timestamp":1696240213000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.13066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,30]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/nmo.13066"],"URL":"https:\/\/doi.org\/10.1111\/nmo.13066","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,30]]},"article-number":"e13066"}}