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Statements were proposed and discussed during several structured meetings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Reflux testing should be performed after cessation of acid suppressive medication in patients with a low likelihood of <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>. In this setting, testing can be either catheter\u2010based or wireless <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\u2010monitoring or <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\u2010impedance monitoring. In patients with a high probability of <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> (esophagitis grade C and D, histology proven Barrett's mucosa &gt;1\u00a0cm, peptic stricture, previous positive <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring) and persistent symptoms, <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\u2010impedance monitoring should be performed on treatment. Recommendations are provided for data acquisition and analysis. Esophageal acid exposure is considered as pathological if acid exposure time (<jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content>) is greater than 6% on <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> testing. Number of reflux episodes and baseline impedance are exploratory metrics that may complement <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content>. Positive symptom reflux association is defined as symptom index (<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>) &gt;50% or symptom association probability (<jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content>) &gt;95%. A positive symptom\u2010reflux association in the absence of pathological <jats:styled-content style=\"fixed-case\">AET<\/jats:styled-content> defines hypersensitivity to reflux.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>The consensus group determined that grade C or D esophagitis, peptic stricture, histology proven Barrett's mucosa &gt;1\u00a0cm, and esophageal acid exposure greater &gt;6% are sufficient to define pathological <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>. Further testing should be considered when none of these criteria are fulfilled.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13067","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T08:42:24Z","timestamp":1490949744000},"page":"1-15","source":"Crossref","is-referenced-by-count":323,"title":["Ambulatory reflux monitoring for diagnosis of gastro\u2010esophageal reflux disease: Update of the Porto consensus and recommendations from an international consensus group"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-7638","authenticated-orcid":false,"given":"S.","family":"Roman","sequence":"first","affiliation":[{"name":"Digestive Physiology Hospices Civils de Lyon and Lyon I University Inserm U1032 LabTAU  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3388-0660","authenticated-orcid":false,"given":"C. 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