{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:51:02Z","timestamp":1791352262327,"version":"4.3.1"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["340101"],"award-info":[{"award-number":["340101"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Electrical stimulation of the cervical vagus nerve (VNS<\/jats:styled-content>) prevents postoperative ileus (POI<\/jats:styled-content>) in mice. As this approach requires an additional cervical procedure, we explored the possibility of peroperative abdominal VNS<\/jats:styled-content> in mice and human.<\/jats:p><\/jats:sec>Methods<\/jats:title>The effect of cervical and abdominal VNS<\/jats:styled-content> was studied in a murine model of POI<\/jats:styled-content> and lipopolysaccharide (LPS<\/jats:styled-content>)\u2010induced sepsis. Postoperative ileus was quantified by assessment of intestinal transit of fluorescent dextran expressed as geometric center (GC<\/jats:styled-content>). Next, the effect of cervical and abdominal VNS<\/jats:styled-content> on heart rate was determined in eight Landrace pigs to select the optimal electrode for VNS<\/jats:styled-content> in human. Finally, the effect of sham or abdominal VNS<\/jats:styled-content> on LPS<\/jats:styled-content>\u2010induced cytokine production of whole blood was studied in patients undergoing colorectal surgery.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Similar to cervical VNS<\/jats:styled-content>, abdominal VNS<\/jats:styled-content> significantly decreased LPS<\/jats:styled-content>\u2010induced serum tumor necrosis factor\u2010\u03b1 (TNF<\/jats:styled-content>\u03b1) levels (abdominal VNS<\/jats:styled-content>: 366\u00b133\u00a0pg\/mL vs sham: 822\u00b1105\u00a0pg\/mL; P<\/jats:italic><.01). In line, in a murine model of POI<\/jats:styled-content>, abdominal VNS<\/jats:styled-content> significantly improved intestinal transit (GC<\/jats:styled-content>: sham 5.1\u00b10.2 vs abdominal VNS<\/jats:styled-content>: 7.8\u00b10.6; P<\/jats:italic><.01) and reduced intestinal inflammation (abdominal VNS<\/jats:styled-content>: 35\u00b17 vs sham: 80\u00b18 myeloperoxidase positive cells\/field; P<\/jats:italic><.05). In pigs, heart rate was reduced by cervical VNS<\/jats:styled-content> but not by abdominal VNS<\/jats:styled-content>. In humans, abdominal VNS<\/jats:styled-content> significantly reduced LPS<\/jats:styled-content>\u2010induced IL<\/jats:styled-content>8 and IL<\/jats:styled-content>6 production by whole blood.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>Abdominal VNS<\/jats:styled-content> is feasible and safe in humans and has anti\u2010inflammatory properties. As abdominal VNS<\/jats:styled-content> improves POI<\/jats:styled-content> similar to cervical VNS<\/jats:styled-content> in mice, our data indicate that peroperative abdominal VNS<\/jats:styled-content> may represent a novel approach to shorten POI<\/jats:styled-content> in man.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13075","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T10:43:03Z","timestamp":1492771383000},"source":"Crossref","is-referenced-by-count":83,"title":["Abdominal vagus nerve stimulation as a new therapeutic approach to prevent postoperative ileus"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6229-0045","authenticated-orcid":false,"given":"N.","family":"Stakenborg","sequence":"first","affiliation":[{"name":"Translational Research Center for GastroIntestinal Disorders (TARGID) Intestinal Neuroimmune Interactions University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Wolthuis","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery University Hospital of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Gomez\u2010Pinilla","sequence":"additional","affiliation":[{"name":"Translational Research Center for GastroIntestinal Disorders (TARGID) Intestinal Neuroimmune Interactions University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Farro","sequence":"additional","affiliation":[{"name":"Translational Research Center for GastroIntestinal Disorders (TARGID) Intestinal Neuroimmune Interactions University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Di Giovangiulio","sequence":"additional","affiliation":[{"name":"Translational Research Center for GastroIntestinal Disorders (TARGID) Intestinal Neuroimmune Interactions University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bosmans","sequence":"additional","affiliation":[{"name":"Translational Research Center for GastroIntestinal Disorders (TARGID) Intestinal Neuroimmune Interactions University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Labeeuw","sequence":"additional","affiliation":[{"name":"Translational Research Center for GastroIntestinal Disorders (TARGID) Intestinal Neuroimmune Interactions University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Verhaegen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University Hospital of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Depoortere","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders Gut Peptide Research Lab University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"D'Hoore","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery University Hospital of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Matteoli","sequence":"additional","affiliation":[{"name":"Translational Research Center for GastroIntestinal Disorders (TARGID) Laboratory of Mucosal Immunology University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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