{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:29:34Z","timestamp":1788470974876,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We have shown that a galactooligosaccharide prebiotic administration (<jats:styled-content style=\"fixed-case\">HOST<\/jats:styled-content>\u2010G904) initially increased intestinal gas production and this increase declined back to baseline after 2\u00a0week administration. Our aim was to determine the mechanism of microbiota adaptation; i.e., to determine whether the net reduction is due to decreased overall production or increased gas consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 10 healthy subjects, intestinal gas production and intraluminal disposal was measured before, at the beginning and after 2\u00a0week of <jats:styled-content style=\"fixed-case\">HOST<\/jats:styled-content>\u2010G904 prebiotic administration. Anal gas was collected for 4 hour after a probe meal. Paired studies were performed without and with high\u2010rate infusion of exogenous gas (24\u00a0mL\/min) into the jejunum to wash\u2010out the endogenous gas produced by bacterial fermentation. The exogenous gas infused was labeled (5% <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content><jats:sub>6<\/jats:sub>) to calculate the proportion of endogenous gas evacuated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The volume of intestinal gas produced i.e., endogenous gas washed\u2010out, increased by 37% at the beginning of <jats:styled-content style=\"fixed-case\">HOST<\/jats:styled-content>\u2010G904 administration (<jats:italic>P<\/jats:italic>=.049 vs preadministration) and decreased down to preadministration level after 2\u00a0week administration (<jats:italic>P<\/jats:italic>=.030 vs early administration). The proportion of gas eliminated from the lumen before reaching the anus tended to increase after 2\u2010week administration (87\u00b13% vs 78\u00b15% preadministration; <jats:italic>P<\/jats:italic>=.098).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Adaptation to regular consumption of <jats:styled-content style=\"fixed-case\">HOST<\/jats:styled-content>\u2010G904 prebiotic involves a shift in microbiota metabolism toward low\u2010gas producing pathways, with a non\u2010significant increase in gas\u2010consuming activity. Hence, regular consumption of <jats:styled-content style=\"fixed-case\">HOST<\/jats:styled-content>\u2010G904 regulates intestinal gas metabolism: less gas is produced and a somewhat larger proportion of it is consumed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13080","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T08:56:39Z","timestamp":1492505799000},"source":"Crossref","is-referenced-by-count":32,"title":["Colonic gas homeostasis: Mechanisms of adaptation following HOST\u2010G904 galactooligosaccharide use in humans"],"prefix":"10.1111","volume":"29","author":[{"given":"M.","family":"Mego","sequence":"first","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Accarino","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Tzortzis","sequence":"additional","affiliation":[{"name":"Clasado Research Services Ltd Science and Technology Centre University of Reading  Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Vulevic","sequence":"additional","affiliation":[{"name":"Clasado Research Services Ltd Science and Technology Centre University of Reading  Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Food Microbial Sciences Unit Department of Food and Nutritional Sciences The University of Reading  Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Guarner","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-960X","authenticated-orcid":false,"given":"F.","family":"Azpiroz","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit University Hospital Vall d'Hebron Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Universitat Aut\u00f2noma de Barcelona  Barcelona 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