{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:22:09Z","timestamp":1782922929143,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,5,7]],"date-time":"2017-05-07T00:00:00Z","timestamp":1494115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have not been able to correlate manometry findings with bolus perception. The aim of this study was to evaluate correlation of different variables, including traditional manometric variables (at diagnostic and extreme thresholds), esophageal shortening, bolus transit, automated impedance manometry (<jats:styled-content style=\"fixed-case\">AIM<\/jats:styled-content>) metrics and mood with bolus passage perception in a large cohort of asymptomatic individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>High resolution manometry (<jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>) was performed in healthy individuals from nine centers. Perception was evaluated using a 5\u2010point Likert scale. Anxiety was evaluated using Hospitalized Anxiety and Depression scale (<jats:styled-content style=\"fixed-case\">HAD<\/jats:styled-content>). Subgroup analysis was also performed classifying studies into normal, hypotensive, vigorous, and obstructive patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>One hundred fifteen studies were analyzed (69 using <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content> and 46 using high resolution impedance manometry (<jats:styled-content style=\"fixed-case\">HRIM<\/jats:styled-content>); 3.5% swallows in 9.6% of volunteers were perceived. There was no correlation of any of the traditional <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content> variables, esophageal shortening, <jats:styled-content style=\"fixed-case\">AIM<\/jats:styled-content> metrics nor bolus transit with perception scores. There was no <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content> variable showing difference in perception when comparing normal vs extreme values (percentile 1 or 99). Anxiety but not depression was correlated with perception. Among hypotensive pattern, anxiety was a strong predictor of variance in perception (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> up to .70).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Inferences<\/jats:title><jats:p>Bolus perception is less common than abnormal motility among healthy individuals. Neither esophageal motor function nor bolus dynamics evaluated with several techniques seems to explain differences in bolus perception. Different mechanisms seem to be relevant in different manometric patterns. Anxiety is a significant predictor of bolus perception in the context of hypotensive motility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13088","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T02:51:51Z","timestamp":1494211911000},"source":"Crossref","is-referenced-by-count":9,"title":["Anxiety can significantly explain bolus perception in the context of hypotensive esophageal motility: Results of a large multicenter study in asymptomatic individuals"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-5192","authenticated-orcid":false,"given":"D.","family":"Cisternas","sequence":"first","affiliation":[{"name":"Universidad del Desarrollo Facultad de Medicina Cl\u00ednica Alemana de Santiago  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Scheerens","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Omari","sequence":"additional","affiliation":[{"name":"Human Physiology, Medical Science and Technology School of Medicine FlindersUniversity  Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Monrroy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hani","sequence":"additional","affiliation":[{"name":"San Ignacio Hospital Pontificia Universidad Javeriana  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Leguizamo","sequence":"additional","affiliation":[{"name":"San Ignacio Hospital Pontificia Universidad Javeriana  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bilder","sequence":"additional","affiliation":[{"name":"Neurogastroenterology School of Medicine Universitary Hospital FundacionFavaloro  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ditaranto","sequence":"additional","affiliation":[{"name":"Neurogastroenterology School of Medicine Universitary Hospital FundacionFavaloro  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ruiz de Le\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"P\u00e9rez de la Serna","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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