{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:42:56Z","timestamp":1793162576564,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_PC_13072"],"award-info":[{"award-number":["MC_PC_13072"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We have previously reported a non\u2010invasive, semi\u2010automated technique to assess motility of the wall of the ascending colon (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>) using Magnetic Resonance Imaging. This study investigated the feasibility of using a tagged <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> technique to visualize and assess the degree of flow within the human ascending colon in healthy subjects and those suffering from constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An open\u2010labeled study of 11 subjects with constipation and 11 subjects without bowel disorders was performed. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scans were acquired fasted, then 60 and 120\u00a0minutes after ingestion of a 500\u00a0mL macrogol preparation. The amount of free fluid in the small and large bowel was assessed using a heavily T2\u2010weighted <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> sequence. The internal movement of the contents of the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> was visualized using a cine tagged <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> sequence and assessed by a novel analysis technique. Comparisons were made between fasting and postprandial scans within individuals, and between the constipation and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Macrogol significantly increased the mobile, <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> visible water content of the ascending colon at 60\u00a0minutes postingestion compared to fasted data (controls <jats:italic>P<\/jats:italic>=.001, constipated group <jats:italic>P<\/jats:italic>=.0039). The contents of the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> showed increased motion in healthy subjects but not in the constipated group with significant differences between groups at 60\u00a0minutes (<jats:italic>P<\/jats:italic>&lt;.002) and 120\u00a0minutes (<jats:italic>P<\/jats:italic>&lt;.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and inferences<\/jats:title><jats:p>This study successfully demonstrated the use of a novel <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> tagging technique to visualize and assess the motion of ascending colon contents following a 500\u00a0mL macrogol challenge. Significant differences were demonstrated between healthy and constipated subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13091","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T05:43:01Z","timestamp":1493098981000},"source":"Crossref","is-referenced-by-count":34,"title":["Assessment of motion of colonic contents in the human colon using <scp>MRI<\/scp> tagging"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4527-6954","authenticated-orcid":false,"given":"S. E.","family":"Pritchard","sequence":"first","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre School of Physics and Astronomy University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Paul","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre School of Physics and Astronomy University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Major","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre School of Medicine University of Nottingham  Nottingham UK"},{"name":"NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and The University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9092-4300","authenticated-orcid":false,"given":"L.","family":"Marciani","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre School of Medicine University of Nottingham  Nottingham UK"},{"name":"NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and The University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Gowland","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre School of Physics and Astronomy University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. C.","family":"Spiller","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre School of Medicine University of Nottingham  Nottingham UK"},{"name":"NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and The University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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