{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:59:55Z","timestamp":1778943595781,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P 18101\u2010B09"],"award-info":[{"award-number":["P 18101\u2010B09"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["L309\u2010B09"],"award-info":[{"award-number":["L309\u2010B09"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Augmented chemosensitivity to capsaicin has been demonstrated in approximately half of functional dyspepsia (FD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We determined clinical characteristics of <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients with and without chemical hypersensitivity at baseline and after capsaicin ingestion for 4\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>N=49 outpatients with confirmed <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> received an oral sensitivity test with 0.75\u00a0mg capsaicin at three occasions, before and after ingesting 0.25\u00a0mg capsaicin tid for 4\u00a0weeks. Symptomatic response to capsaicin allowed stratification to a capsaicin positive (chemosensitive) and a capsaicin negative (not chemosensitive) patient group. Symptom diaries were completed in the week before and during capsaicin ingestion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 53% <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> had a positive capsaicin test, Crohnbach alpha was 0.85. Basic clinical characteristics were comparable in capsaicin positive and negative <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>, but median daily aggregate upper gastrointestinal symptoms scores were significantly higher in capsaicin positive (median: 9.4; 5.4\/11.7) than in capsaicin negative patients (6.6; 4.1\/8.1) (<jats:italic>P<\/jats:italic>&lt;.05). After capsaicin ingestion, upper gastrointestinal symptoms scores were reduced by \u22123.3 (\u22124.9\/\u22121.9; <jats:italic>P<\/jats:italic>&lt;.001) in capsaicin positive and \u22122.6 (\u22123.8\/\u22120.3; <jats:italic>P<\/jats:italic>&lt;.05) in capsaicin negative patients. Lower abdominal symptoms were comparable in capsaicin positive and negative patients at baseline (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). After capsaicin ingestion lower gastrointestinal symptoms scores were reduced by \u22121.0 (\u22121.8\/\u22120.1; <jats:italic>P<\/jats:italic>&lt;.05) in capsaicin positive but not significantly altered (\u22120.6; \u22121.7\/+0.9; <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>) in capsaicin negative patients. After long\u2010term capsaicin ingestion, the capsaicin test turned negative in 53% of chemosensitive patients (<jats:italic>P<\/jats:italic>&lt;.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Differences in upper <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> symptoms distinguished capsaicin positive and negative patients. Symptom improvement after long\u2010term capsaicin ingestion was indirect proportional to the capsaicin test result.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13103","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T04:22:43Z","timestamp":1495772563000},"page":"1-12","source":"Crossref","is-referenced-by-count":19,"title":["Clinical characteristics of functional dyspepsia depending on chemosensitivity to capsaicin"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-1201","authenticated-orcid":false,"given":"J.","family":"Hammer","sequence":"first","affiliation":[{"name":"Abteilung f\u00fcr Gastroenterologie und Hepatologie Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"F\u00fchrer","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Gastroenterologie und Hepatologie Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00900.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.029793"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2004.01823.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00997.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12044"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01766.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01227.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03022.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2010.16.2.131"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01280.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.07.028"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00039-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01734.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.149724"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12291"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2009.04.007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_9_20_1","unstructured":"HammerJ.Symptoms induced by gastric application of capsaicin discriminate ERD patients from healthy controls. 11th World Conference of OESO; 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