{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:27:15Z","timestamp":1793035635709,"version":"4.5.0"},"reference-count":127,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:00:00Z","timestamp":1495584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"United European Gastroenterology (UEG)","id":[{"id":"https:\/\/ror.org\/005hr7v68","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n High\u2010resolution manometry (\n HRM<\/jats:styled-content>\n ) has resulted in new revelations regarding the pathophysiology of gastro\u2010esophageal reflux disease (\n GERD<\/jats:styled-content>\n ). The impact of new\n HRM<\/jats:styled-content>\n motor paradigms on reflux burden needs further definition, leading to a modern approach to motor testing in\n GERD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Focused literature searches were conducted, evaluating pathophysiology of\n GERD<\/jats:styled-content>\n with emphasis on\n HRM<\/jats:styled-content>\n . The results were discussed with an international group of experts to develop a consensus on the role of\n HRM<\/jats:styled-content>\n in\n GERD<\/jats:styled-content>\n . A proposed classification system for esophageal motor abnormalities associated with\n GERD<\/jats:styled-content>\n was generated.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n Physiologic gastro\u2010esophageal reflux is inherent in all humans, resulting from transient lower esophageal sphincter (\n LES<\/jats:styled-content>\n ) relaxations that allow venting of gastric air in the form of a belch. In pathological gastro\u2010esophageal reflux, transient\n LES<\/jats:styled-content>\n relaxations are accompanied by reflux of gastric contents. Structural disruption of the esophagogastric junction (\n EGJ<\/jats:styled-content>\n ) barrier, and incomplete clearance of the refluxate can contribute to abnormally high esophageal reflux burden that defines\n GERD<\/jats:styled-content>\n . Esophageal\n HRM<\/jats:styled-content>\n localizes the\n LES<\/jats:styled-content>\n for\n pH<\/jats:styled-content>\n and\n pH<\/jats:styled-content>\n \u2010impedance probe placement, and assesses esophageal body peristaltic performance prior to invasive antireflux therapies and antireflux surgery. Furthermore,\n HRM<\/jats:styled-content>\n can assess\n EGJ<\/jats:styled-content>\n and esophageal body mechanisms contributing to reflux, and exclude conditions that mimic GERD.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n Structural and motor\n EGJ<\/jats:styled-content>\n and esophageal processes contribute to the pathophysiology of\n GERD<\/jats:styled-content>\n . A classification scheme is proposed incorporating\n EGJ<\/jats:styled-content>\n and esophageal motor findings, and contraction reserve on provocative tests during\n HRM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.13104","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T12:13:31Z","timestamp":1495714411000},"source":"Crossref","is-referenced-by-count":189,"title":["Classification of esophageal motor findings in gastro\u2010esophageal reflux disease: Conclusions from an international consensus group"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3388-0660","authenticated-orcid":false,"given":"C. 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