{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T04:23:59Z","timestamp":1772943839993,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Royal Netherlands Academy of Arts and Sciences (Academy Ter Meulen Grant)"},{"name":"European Society for Pediatric Gastroenterology, Hepatology and Nutrition (Charlotte Anderson Travel Award)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Colonic dilation is common in children with intractable functional constipation (<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>). Our aim was to describe the association between segmental colonic dilation and colonic dysmotility in children with <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study on 30 children with intractable <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> (according to the Rome <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> criteria) who had undergone colonic manometry and contrast enema within a 12\u2010month time period. Colonic diameter was measured at 5\u00a0cm intervals from the anal verge up to the splenic flexure. Moreover, the distance between the lateral margins of the pedicles of vertebra L2 was measured to provide a ratio (colonic diameter or length\/distance between the lateral margins; \u201cstandardized colon size\u201d [<jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content>]). All manometry recordings were visually inspected for the presence of high\u2010amplitude propagating contractions (<jats:styled-content style=\"fixed-case\">HAPC<\/jats:styled-content>s); a parameter for colonic motility integrity. The intracolonic location of the manometry catheter sensors was assessed using an abdominal X\u2010ray.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Colonic segments with <jats:styled-content style=\"fixed-case\">HAPC<\/jats:styled-content>s had a significantly smaller median diameter than colonic segments without <jats:styled-content style=\"fixed-case\">HAPC<\/jats:styled-content>s (4.08\u00a0cm vs 5.48\u00a0cm, <jats:italic>P<\/jats:italic>&lt;.001; <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> 1.14 vs 1.66, <jats:italic>P<\/jats:italic>=.001). Children with prematurely terminating <jats:styled-content style=\"fixed-case\">HAPC<\/jats:styled-content>s had significantly larger <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> ratios for colonic diameter than children with fully propagating <jats:styled-content style=\"fixed-case\">HAPC<\/jats:styled-content>s (<jats:italic>P<\/jats:italic>=.008). <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> ratios for the length of the rectosigmoid and the descending colon and the <jats:styled-content style=\"fixed-case\">SCS<\/jats:styled-content> ratio for sigmoid colon diameter were significantly larger in children with <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> compared to a previously described normative population (<jats:italic>P<\/jats:italic>&lt;.0001, <jats:italic>P<\/jats:italic>&lt;.0001 and <jats:italic>P<\/jats:italic>=.0007 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Segmental colonic dilation was associated with prematurely terminating <jats:styled-content style=\"fixed-case\">HAPC<\/jats:styled-content>s and may be a useful indicator of colonic dysmotility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13110","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T10:42:53Z","timestamp":1495190573000},"page":"1-9","source":"Crossref","is-referenced-by-count":20,"title":["Segmental colonic dilation is associated with premature termination of high\u2010amplitude propagating contractions in children with intractable functional constipation"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1856-0968","authenticated-orcid":false,"given":"I. J. N.","family":"Koppen","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Department of Pediatrics Nationwide Children's Hospital  Columbus OH USA"},{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children's Hospital\/Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. P.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Radiology Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. J.","family":"Ambeba","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research The Research Institute at Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. A.","family":"Lane","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research The Research Institute at Nationwide Children's Hospital  Columbus OH USA"},{"name":"Division of Pediatric Surgery Department of Surgery Nationwide Children's Hospital  Columbus OH USA"},{"name":"Department of Surgery Center for Colorectal and Pelvic Reconstruction Nationwide Children's Hospital The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. G.","family":"Bates","sequence":"additional","affiliation":[{"name":"Department of Radiology Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. C.","family":"Minneci","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research The Research Institute at Nationwide Children's Hospital  Columbus OH USA"},{"name":"Division of Pediatric Surgery Department of Surgery Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Deans","sequence":"additional","affiliation":[{"name":"Center for Surgical Outcomes Research The Research Institute at Nationwide Children's Hospital  Columbus OH USA"},{"name":"Division of Pediatric Surgery Department of Surgery Nationwide Children's Hospital  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Levitt","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Nationwide Children's Hospital  Columbus OH USA"},{"name":"Department of Surgery Center for Colorectal and Pelvic Reconstruction Nationwide Children's Hospital The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Wood","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Nationwide Children's Hospital  Columbus OH USA"},{"name":"Department of Surgery Center for Colorectal and Pelvic Reconstruction Nationwide Children's Hospital The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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