{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:42:08Z","timestamp":1761709328132,"version":"3.41.2"},"reference-count":63,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007658","name":"Crohn's and Colitis Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Changes to the structure and function of the innervation of the gut contribute to symptom generation in inflammatory bowel diseases (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>). However, delineation of the mechanisms of these effects has proven difficult. Previous work on sympathetic neurons identified interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201017A as a novel neurotrophic cytokine. Since <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A is involved in <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> pathogenesis, we tested the hypothesis that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A contributes to neuroanatomical remodeling during <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistochemistry for tyrosine hydroxylase was used to identify sympathetic axons in mice with dextran sulphate sodium (DSS)\u2010induced colitis and controls. Axon outgrowth from sympathetic neurons in response to incubation in cytokines or endoscopic patient biopsy supernatants was quantified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010induced colitis led to an increase in tyrosine hydroxylase immunoreactivity in the inflamed colon but not the spleen. Colonic supernatants from mice with colitis and biopsy supernatants from Crohn's disease patients increased axon outgrowth from mouse sympathetic neurons compared to supernatants from uninflamed controls. An antibody that neutralized <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A blocked the ability of <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010induced colitis and Crohn's disease supernatants to induce axon extension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>These findings identify <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A as a potential mediator of neuroanatomical remodeling of the gut innervation during <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13112","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T04:33:08Z","timestamp":1496205188000},"source":"Crossref","is-referenced-by-count":5,"title":["A role for interleukin 17A in <scp>IBD<\/scp>\u2010related neuroplasticity"],"prefix":"10.1111","volume":"29","author":[{"given":"A. 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