{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T10:10:11Z","timestamp":1769940611527,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A recent multicenter randomized trial in achalasia patients has shown that pneumatic dilation resulted in equivalent relief of symptoms compared to laparoscopic Heller myotomy. Additionally, the cost of each treatment should be also taken in consideration. Therefore, the aim of the present study was to perform an economic analysis of the European achalasia trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with newly diagnosed achalasia were enrolled from to 2003 to 2008 in 14 centers in five European countries and were randomly assigned to either pneumatic dilation (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) or laparoscopic Heller (<jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content>). The economic analysis was performed in the three centers in three different countries where most patients were enrolled (Amsterdam [<jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content>], Leuven, [B] and Padova [I]) and then applied to all patients included in the study. The total raw costs of the two treatments per patient include the initial costs, the costs of complications, and the costs of retreatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and one patients, 107 (57 males and 50 females, mean age 46 <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 43\u201049\u00a0years) were randomized to <jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content> and 94 (59 males and 34 females, mean age 46 <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 43\u201050\u00a0years) to <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. The total cost of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> per patient was quite comparable in the three different centers; \u20ac3397 in Padova, \u20ac3259 in Amsterdam and \u20ac3792 in Leuven. For <jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content>, the total costs per patient were highest in Amsterdam: \u20ac4488 in Padova, \u20ac6720 in Amsterdam, and \u20ac5856 in Leuven.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, the strategy of treating achalasia starting with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> appears the most economic approach, independent of the health system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13115","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T04:42:40Z","timestamp":1495773760000},"source":"Crossref","is-referenced-by-count":11,"title":["Economic evaluation of the randomized European Achalasia trial comparing pneumodilation with Laparoscopic Heller myotomy"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-2728","authenticated-orcid":false,"given":"A.","family":"Moonen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Catholic University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Busch","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Costantini","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncological and Gastroenterological Sciences University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Finotti","sequence":"additional","affiliation":[{"name":"Department of Surgery Policlinico di Abano Terme  Abano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-6704","authenticated-orcid":false,"given":"J.","family":"Tack","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Catholic University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Salvador","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncological and Gastroenterological Sciences University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Boeckxstaens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Catholic University of Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Zaninotto","sequence":"additional","affiliation":[{"name":"Department of Academic Surgery St Mary's Hospital Imperial College  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2012.11.009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60651-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/MCG.0000000000000137","article-title":"Current diagnosis and management of achalasia","volume":"48","author":"Moonen A","year":"2014","journal-title":"J Clin Gastroenterol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.5.490"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02637121"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.11.017"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.035"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.212423"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010502"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310602"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-007-9364-z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015811001267"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03181.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-007-9310-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296777"}],"container-title":["Neurogastroenterology &amp; 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