{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:16:23Z","timestamp":1777414583725,"version":"3.51.4"},"reference-count":60,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Colonic pseudo\u2010obstruction (CPO<\/jats:styled-content>) is characterized by colonic distention in the absence of mechanical obstruction or toxic megacolon. Concomitant secretory diarrhea (SD<\/jats:styled-content>) with hypokalemia (SD<\/jats:styled-content>\u2010CPO<\/jats:styled-content>) due to gastrointestinal (GI<\/jats:styled-content>) loss requires further characterization.<\/jats:p><\/jats:sec>Aim<\/jats:title>To perform a systematic review of SD<\/jats:styled-content>\u2010CPO<\/jats:styled-content>, report a case study, and compare SD<\/jats:styled-content>\u2010CPO<\/jats:styled-content> with classical CPO<\/jats:styled-content> (C\u2010CPO<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed a search of MEDLINE<\/jats:styled-content>, EMBASE<\/jats:styled-content>, Cochrane, and Scopus for reports based on a priori criteria for CPO<\/jats:styled-content>, SD<\/jats:styled-content> and GI<\/jats:styled-content> loss of potassium. An additional case at Mayo Clinic was included.<\/jats:p><\/jats:sec>Results<\/jats:title>Nine publications met inclusion criteria, with a total of 14 cases. Six studies had high, three moderate, and our case high methodological quality. Median age was 74\u00a0years (66\u201097), with 2:1 male\/female ratio. Kidney disease was present in 6\/14 patients. Diarrhea was described as profuse, watery, or viscous in 10 patients. Median serum, stool, and urine potassium concentrations (mmol\/L) were 2.4 (range: 1.9\u20103.1), 137 (100\u2010180), and 17 (8\u201040), respectively. Maximal diameter of colon and cecum (median) were 10.2\u00a0cm and 10.5\u00a0cm, respectively. Conservative therapy alone was effective in five out of 14 patients. Median potassium supplementation was 124\u00a0mEq\/d (40\u2010300). Colonic decompression was effective in three out of six patients; one had a total colectomy; three out of 14 had died. The main differences between SD<\/jats:styled-content>\u2010CPO<\/jats:styled-content> and C\u2010CPO<\/jats:styled-content> were lower responses to treatments: conservative measures (35.7% vs 73.6%, P<\/jats:italic>=.01), neostigmine (17% vs 89.2%, P<\/jats:italic><.001), and colonic decompression (50% vs 82.4%, P<\/jats:italic>=.02).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>SD<\/jats:styled-content>\u2010CPO<\/jats:styled-content> is a rare phenotype associated with increased fecal potassium and is more difficult to treat than C\u2010CPO<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13120","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T08:06:41Z","timestamp":1496650001000},"source":"Crossref","is-referenced-by-count":32,"title":["Secretory diarrhea and hypokalemia associated with colonic pseudo\u2010obstruction: A case study and systematic analysis of the literature"],"prefix":"10.1111","volume":"29","author":[{"given":"F.","family":"Bazerbachi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Haffar","sequence":"additional","affiliation":[{"name":"Digestive Center for Diagnosis and Treatment Damascus Syrian Arab Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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Kern Center for the Science of Health Care Delivery Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-7514","authenticated-orcid":false,"given":"M.","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Camilleri M.Acute colonic pseudo\u2010obstruction (Ogilvie's syndrome). UpToDate Waltham MA. 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