{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:38:38Z","timestamp":1780439918689,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>There have been no empirical validations of the Rome III<\/jats:styled-content> or Rome IV<\/jats:styled-content> criteria in children. The aim of the current study was to examine whether symptoms naturally occur in a pattern consistent with Rome III<\/jats:styled-content> and\/or Rome IV<\/jats:styled-content> pediatric criteria for functional dyspepsia (FD<\/jats:styled-content>) and irritable bowel syndrome (IBS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a retrospective cohort study of 250 children, ages 8\u201017\u00a0years, presenting to an abdominal pain clinic with pain of at least 8\u00a0weeks duration. We evaluated patterns of gastrointestinal (GI<\/jats:styled-content>) and non\u2010gastrointestinal (non\u2010GI<\/jats:styled-content>) symptoms which had been collected in a standardized fashion as part of routine clinical care. Confirmatory factor analyses were used to compare pre\u2010existing models of symptoms clusters, namely Rome III<\/jats:styled-content> and Rome IV<\/jats:styled-content> criteria for IBS<\/jats:styled-content> and FD<\/jats:styled-content> in children and adolescents. Factor intercorrelations also were examined to determine whether IBS<\/jats:styled-content> symptoms and non\u2010GI<\/jats:styled-content> somatic complaints correlate uniquely with FD<\/jats:styled-content> symptom clusters.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Both models demonstrated good fit with observed data [3\u2010factor: \u03c72<\/jats:sup> (101, n=250)110.75, P<\/jats:italic><.05, TLI<\/jats:styled-content>=.99, CFI<\/jats:styled-content>=.99; 4\u2010factor: \u03c72<\/jats:sup>(98, n=250)117.54, P<\/jats:italic><.05, TLI<\/jats:styled-content>=.96, CFI<\/jats:styled-content>=.97]. Fit indices and intercorrelations favored the more parsimonious 3\u2010factor solution (3\u2010factor: AIC<\/jats:styled-content>=4654.91, BIC<\/jats:styled-content>=4778.17; 4\u2010factor: AIC<\/jats:styled-content>=4757.16, BIC<\/jats:styled-content>=4890.97) consistent with pediatric Rome III<\/jats:styled-content> criteria that conceptualizes FD<\/jats:styled-content> as a single diagnostic category. FD<\/jats:styled-content> demonstrated significant overlap with IBS<\/jats:styled-content> (.42), while non\u2010GI<\/jats:styled-content>\u2010specific symptoms correlated significantly with FD<\/jats:styled-content> (.64), but not IBS<\/jats:styled-content> (.14) symptoms.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>GI<\/jats:styled-content> symptoms in children presenting for initial evaluation of chronic functional abdominal pain occur in a pattern consistent with Rome III<\/jats:styled-content> and IV<\/jats:styled-content> pediatric criteria. Rome III<\/jats:styled-content> offers a more parsimonious model. The presence of FD<\/jats:styled-content> symptoms is strongly, and uniquely, associated with non\u2010GI<\/jats:styled-content> symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.13126","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T07:56:43Z","timestamp":1498636603000},"source":"Crossref","is-referenced-by-count":7,"title":["Examination of competing diagnostic models of functional gastrointestinal disorders related to pain in children"],"prefix":"10.1111","volume":"29","author":[{"given":"J. V.","family":"Schurman","sequence":"first","affiliation":[{"name":"Division of Developmental and Behavioral Sciences Children's Mercy Kansas City Kansas MO 64108 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. T.","family":"Karazsia","sequence":"additional","affiliation":[{"name":"Department of Psychology 930 College Mall The College of Wooster Wooster OH 44691 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-0967","authenticated-orcid":false,"given":"C. 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